Pre-conditioned place preference treatment of chloral hydrate interrupts the rewarding effect of morphine

Y.M. Sun, W. Zong, M.R. Zhou, Y.Y. Ma, J.H. Wang

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The medical use of morphine as a pain killer is hindered by its side effects including dependence and further addiction. As the prototypical μ receptor agonist, morphine's rewarding effect can be measured by conditioned place preference (CPP) paradigms in animals. Chloral hydrate is a clinical sedative. Using a morphine CPP paradigm that mainly contains somatosensory cues, we found that pre-CPP treatment in rats using chloral hydrate for 6 consecutive days could disrupt the establishment of CPP in a U shape. Chloral hydrate had no effect on the body weight of rats. Our results indicate that prior treatment with chloral hydrate can interrupt the rewarding effect of morphine.
Original languageEnglish
Pages (from-to)60-63
JournalPharmacology, Biochemistry and Behavior
Volume135
DOIs
Publication statusPublished - 2015

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