TY - JOUR
T1 - Pre-conditioned place preference treatment of chloral hydrate interrupts the rewarding effect of morphine
AU - Sun, Y.M.
AU - Zong, W.
AU - Zhou, M.R.
AU - Ma, Y.Y.
AU - Wang, J.H.
PY - 2015
Y1 - 2015
N2 - The medical use of morphine as a pain killer is hindered by its side effects including dependence and further addiction. As the prototypical μ receptor agonist, morphine's rewarding effect can be measured by conditioned place preference (CPP) paradigms in animals. Chloral hydrate is a clinical sedative. Using a morphine CPP paradigm that mainly contains somatosensory cues, we found that pre-CPP treatment in rats using chloral hydrate for 6 consecutive days could disrupt the establishment of CPP in a U shape. Chloral hydrate had no effect on the body weight of rats. Our results indicate that prior treatment with chloral hydrate can interrupt the rewarding effect of morphine.
AB - The medical use of morphine as a pain killer is hindered by its side effects including dependence and further addiction. As the prototypical μ receptor agonist, morphine's rewarding effect can be measured by conditioned place preference (CPP) paradigms in animals. Chloral hydrate is a clinical sedative. Using a morphine CPP paradigm that mainly contains somatosensory cues, we found that pre-CPP treatment in rats using chloral hydrate for 6 consecutive days could disrupt the establishment of CPP in a U shape. Chloral hydrate had no effect on the body weight of rats. Our results indicate that prior treatment with chloral hydrate can interrupt the rewarding effect of morphine.
UR - https://www.scopus.com/pages/publications/84930675120
UR - https://www.scopus.com/inward/citedby.url?scp=84930675120&partnerID=8YFLogxK
U2 - 10.1016/j.pbb.2015.05.010
DO - 10.1016/j.pbb.2015.05.010
M3 - Article
SN - 0091-3057
VL - 135
SP - 60
EP - 63
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
ER -
