Precision analysis and optimization in phase decorrelation OCT velocimetry

Maximilian G.O. Gräfe; Maude Gondre; Johannes F. de Boer

doi:10.1364/BOE.10.001297

Precision analysis and optimization in phase decorrelation OCT velocimetry

Maximilian G.O. Gräfe
, Maude Gondre
, Johannes F. de Boer^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Quantitative flow velocimetry in Optical Coherence Tomography is used to determine both the axial and lateral flow component at the level of individual voxels. The lateral flow is determined by analyzing the statistical properties of reflected electro-magnetic fields for repeated measurements at (nearly) the same location. The precision or statistical fluctuation of the quantitative velocity estimation depends on the number of repeated measurements and the method to determine quantitative flow velocity. In this paper, both a method to determine quantitative flow velocity and a model for the prediction of the statistical fluctuations of velocity estimations are developed to analyze and optimize the estimation precision for phase-based velocimetry methods. The method and model are validated by phantom measurements in a bulk scattering medium as well as in intralipid solution in a capillary. Based on the model, the number of repeated measurements to achieve a certain velocimetry precision is predicted.

Original language	English
Article number	351615
Pages (from-to)	1297-1314
Number of pages	18
Journal	Biomedical Optics Express
Volume	10
Issue number	3
DOIs	https://doi.org/10.1364/BOE.10.001297
Publication status	Published - 1 Mar 2019

Funding

The Dutch Technology Foundation STW (grant number 12822), which is part of the Netherlands Organisation for Scientific Research (NWO); the Ministry of Economic Affairs; the Health~Holland framework; the European Union's Horizon 2020 research and innovation program (654148); LaserLaB Europe and Heidelberg Engineering GmbH.

Funders	Funder number
European Union's Horizon 2020 research and innovation program
Health~Holland framework
LaserLaB Europe and Heidelberg Engineering GmbH
Horizon 2020 Framework Programme	654148
Ministerie van Economische Zaken
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Stichting voor de Technische Wetenschappen	12822

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10.1364/BOE.10.001297

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420279

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AB - Quantitative flow velocimetry in Optical Coherence Tomography is used to determine both the axial and lateral flow component at the level of individual voxels. The lateral flow is determined by analyzing the statistical properties of reflected electro-magnetic fields for repeated measurements at (nearly) the same location. The precision or statistical fluctuation of the quantitative velocity estimation depends on the number of repeated measurements and the method to determine quantitative flow velocity. In this paper, both a method to determine quantitative flow velocity and a model for the prediction of the statistical fluctuations of velocity estimations are developed to analyze and optimize the estimation precision for phase-based velocimetry methods. The method and model are validated by phantom measurements in a bulk scattering medium as well as in intralipid solution in a capillary. Based on the model, the number of repeated measurements to achieve a certain velocimetry precision is predicted.

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Precision analysis and optimization in phase decorrelation OCT velocimetry

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