Preclinical models of head and neck squamous cell carcinoma

C. L. Zuur; A. J.C. Dohmen; Michiel W. van den Brekel; Xiao Jing Wang; Stephen Malkosky

doi:10.1007/978-3-319-27601-4_10

Preclinical models of head and neck squamous cell carcinoma

C. L. Zuur, A. J.C. Dohmen, Michiel W. van den Brekel, Xiao Jing Wang, Stephen Malkosky

Maxillofacial Surgery (AMC)

Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic › peer-review

Abstract

HNSCCs are characterized by a broad genetic diversity, likely from prolonged carcinogen exposure and high levels of genetic instability. To date, this high genetic heterogeneity of HNSCC has hampered the development of targeted therapy, and routine use of molecular markers for treatment selection is not established. This chapter reviews preclinical models of HNSCC as a critical tool for exploring tumor initiation and progression, cancer genetics, novel therapeutic approaches, and predictors of clinical response. HNSCC model systems including cancer cell lines derived from human HNSCC, primary human fresh tumor cultures, animals exposed to oral carcinogens, genetically engineered mouse models (GEMMs), and various combinations of these systems are discussed.

Original language	English
Title of host publication	Head and Neck Cancer
Subtitle of host publication	Multimodality Management, Second Edition
Publisher	Springer International Publishing
Pages	205-213
Number of pages	9
ISBN (Electronic)	9783319276014
ISBN (Print)	9783319275994
DOIs	https://doi.org/10.1007/978-3-319-27601-4_10
Publication status	Published - 1 Jan 2016

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© Springer International Publishing Switzerland 2011, 2016.

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AU - Malkosky, Stephen

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Preclinical models of head and neck squamous cell carcinoma

Abstract

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