TY - JOUR
T1 - Predictors of health-related quality of life in patients treated with hematopoietic stem cell transplantation
AU - Braamse, A.M.J.
AU - Gerrits, M.J.G.
AU - van Meijel, B.
AU - Visser, O.
AU - van Oppen, P.
AU - Boenink, A.D.
AU - Cuijpers, P.
AU - Huijgens, P.C.
AU - Beekman, A.T.F.
AU - Dekker, J.
PY - 2012
Y1 - 2012
N2 - Identifying factors that predict health-related quality of life (QOL) following hematopoietic SCT, is important in estimating patients' abilities to adjust to the consequences of their disease and treatment. As the studies that have been published on this subject are scattered, the present study aimed to systematically review prognostic factors for health-related QOL after auto- and allo-SCT in hematological malignancies. A systematic, computerized search in Medline, EMBASE, PsycINFO and the Cochrane Library was conducted from 2002 to June 2010. The methodological quality of the studies was assessed using an adaptation of Hayden's criteria list. Qualitative data synthesis was performed to determine the strength of the scientific evidence. In all, 35 studies fulfilled the selection criteria. Strong-moderate evidence was found for GVHD, conditioning regimen, being female, younger age, receiving less social support and pre-transplant psychological distress as predictors of various aspects of health-related QOL following hematopoietic SCT. The results of this review may help transplant teams in selecting patients at risk for experiencing a diminished health-related QOL following hematopoietic SCT. Follow-up treatment can be provided in order to promote QOL. © 2012 Macmillan Publishers Limited All rights reserved.
AB - Identifying factors that predict health-related quality of life (QOL) following hematopoietic SCT, is important in estimating patients' abilities to adjust to the consequences of their disease and treatment. As the studies that have been published on this subject are scattered, the present study aimed to systematically review prognostic factors for health-related QOL after auto- and allo-SCT in hematological malignancies. A systematic, computerized search in Medline, EMBASE, PsycINFO and the Cochrane Library was conducted from 2002 to June 2010. The methodological quality of the studies was assessed using an adaptation of Hayden's criteria list. Qualitative data synthesis was performed to determine the strength of the scientific evidence. In all, 35 studies fulfilled the selection criteria. Strong-moderate evidence was found for GVHD, conditioning regimen, being female, younger age, receiving less social support and pre-transplant psychological distress as predictors of various aspects of health-related QOL following hematopoietic SCT. The results of this review may help transplant teams in selecting patients at risk for experiencing a diminished health-related QOL following hematopoietic SCT. Follow-up treatment can be provided in order to promote QOL. © 2012 Macmillan Publishers Limited All rights reserved.
U2 - 10.1038/bmt.2011.130
DO - 10.1038/bmt.2011.130
M3 - Article
SN - 0268-3369
VL - 47
SP - 757
EP - 769
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 6
ER -
