Predictors of resilience in older adults with lower limb osteoarthritis and persistent severe pain

Natasja M. van Schoor; Erik J. Timmermans; Martijn Huisman; Alicia Gutiérrez-Misis; Willem Lems; Elaine M. Dennison; Maria Victoria Castell; Michael D. Denkinger; Nancy L. Pedersen; Stefania Maggi; Dorly J.H. Deeg

doi:10.1186/s12877-022-02926-7

Predictors of resilience in older adults with lower limb osteoarthritis and persistent severe pain

Natasja M. van Schoor^*, Erik J. Timmermans, Martijn Huisman, Alicia Gutiérrez-Misis, Willem Lems, Elaine M. Dennison, Maria Victoria Castell, Michael D. Denkinger, Nancy L. Pedersen, Stefania Maggi, Dorly J.H. Deeg

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Resilience refers to the process in which people function well despite adversity. Persistent severe pain may be considered an adversity in people with lower limb osteoarthritis (LLOA). The objectives of this study are: (1) to identify what proportion of older adults with LLOA and persistent severe pain show good functioning; and (2) to explore predictors of resilience. Methods: Data from the European Project on OSteoArthritis (EPOSA) were used involving standardized data from six European population-based cohort studies. LLOA is defined as clinical knee and/or hip osteoarthritis. Persistent severe pain is defined as the highest tertile of the pain subscale of the Western Ontario and McMaster Universities Osteoarthritis Index both at baseline and follow-up. Resilience is defined as good physical, mental or social functioning at follow-up despite having LLOA with persistent severe pain. Results: In total, 95 (14.9%) out of 638 individuals with LLOA had persistent severe pain. Among these, 10 (11.0%), 54 (57.4%) and 49 (53.8%) had good physical, mental and social functioning, respectively. Only 4 individuals (4.5%) were resilient in all three domains of functioning. Younger age, male sex, higher education, higher mastery, smoking and alcohol use, higher physical activity levels, absence of chronic diseases, and more contacts with friends predicted resilience in one or more domains of functioning. Conclusions: Few people with LLOA and persistent severe pain showed good physical functioning and about half showed good mental or social functioning. Predictors of resilience differed between domains, and might provide new insights for treatment.

Original language	English
Article number	246
Pages (from-to)	1-9
Number of pages	9
Journal	BMC Geriatrics
Volume	22
DOIs	https://doi.org/10.1186/s12877-022-02926-7
Publication status	Published - 24 Mar 2022

Bibliographical note

Funding Information:
The Indicators for Monitoring COPD and Asthma—Activity and Function in the Elderly in Ulm study (IMCA—ActiFE) was supported by the European Union (grant number 2005121) and the Ministry of Science, Baden-Württemberg. The Italian cohort was supported by the National Research Council of Italy (CNR), Research Project “Aging: molecular and technological innovations for improving the health of the elderly population” (Prot. MIUR 2867). The Longitudinal Aging Study Amsterdam (LASA) is financially supported by the Dutch Ministry of Health, Welfare and Sports (grant number 311669). The Peñagrande study was partially supported by the National Fund for Health Research (Fondo de Investigaciones en Salud) of Spain (grant numbers FIS PI 05/1898, FIS RETICEF RD06/0013/1013, FIS PS09/02143). The Swedish Twin Registry is managed by Karolinska Institutet and receives funding through the Swedish Research Council (grant number 2017–00641). The Hertfordshire Cohort Study is supported by the Medical Research Council of Great Britain, Versus Arthritis, the British Heart Foundation and the International Osteoporosis Foundation (grant number MRC_MC_UP_A620_1014). The funders were not involved in the study design, data collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.

Publisher Copyright:
© 2022, The Author(s).

Funding

The Indicators for Monitoring COPD and Asthma—Activity and Function in the Elderly in Ulm study (IMCA—ActiFE) was supported by the European Union (grant number 2005121) and the Ministry of Science, Baden-Württemberg. The Italian cohort was supported by the National Research Council of Italy (CNR), Research Project “Aging: molecular and technological innovations for improving the health of the elderly population” (Prot. MIUR 2867). The Longitudinal Aging Study Amsterdam (LASA) is financially supported by the Dutch Ministry of Health, Welfare and Sports (grant number 311669). The Peñagrande study was partially supported by the National Fund for Health Research (Fondo de Investigaciones en Salud) of Spain (grant numbers FIS PI 05/1898, FIS RETICEF RD06/0013/1013, FIS PS09/02143). The Swedish Twin Registry is managed by Karolinska Institutet and receives funding through the Swedish Research Council (grant number 2017–00641). The Hertfordshire Cohort Study is supported by the Medical Research Council of Great Britain, Versus Arthritis, the British Heart Foundation and the International Osteoporosis Foundation (grant number MRC_MC_UP_A620_1014). The funders were not involved in the study design, data collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.

Funders	Funder number
Elderly in Ulm study
Ministry of Science
National Fund for Health Research	FIS PS09/02143, RD06/0013/1013, FIS PI 05/1898
Industrial Macromolecular Crystallography Association Collaborative Access Team
Medical Research Council
British Heart Foundation
European Commission	2005121
European Commission
Ministerie van Volksgezondheid, Welzijn en Sport	311669
Ministerie van Volksgezondheid, Welzijn en Sport
Karolinska Institutet
Vetenskapsrådet	2017–00641
Vetenskapsrådet
Consiglio Nazionale delle Ricerche	MIUR 2867
Consiglio Nazionale delle Ricerche
International Osteoporosis Foundation	MRC_MC_UP_A620_1014
International Osteoporosis Foundation
Versus Arthritis

Keywords

Older Adults
Osteoarthritis
Pain
Predictors
Resilience

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10.1186/s12877-022-02926-7

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Cite this

@article{c298e0c7cdc94a5db4bcb84742936062,

title = "Predictors of resilience in older adults with lower limb osteoarthritis and persistent severe pain",

abstract = "Background: Resilience refers to the process in which people function well despite adversity. Persistent severe pain may be considered an adversity in people with lower limb osteoarthritis (LLOA). The objectives of this study are: (1) to identify what proportion of older adults with LLOA and persistent severe pain show good functioning; and (2) to explore predictors of resilience. Methods: Data from the European Project on OSteoArthritis (EPOSA) were used involving standardized data from six European population-based cohort studies. LLOA is defined as clinical knee and/or hip osteoarthritis. Persistent severe pain is defined as the highest tertile of the pain subscale of the Western Ontario and McMaster Universities Osteoarthritis Index both at baseline and follow-up. Resilience is defined as good physical, mental or social functioning at follow-up despite having LLOA with persistent severe pain. Results: In total, 95 (14.9%) out of 638 individuals with LLOA had persistent severe pain. Among these, 10 (11.0%), 54 (57.4%) and 49 (53.8%) had good physical, mental and social functioning, respectively. Only 4 individuals (4.5%) were resilient in all three domains of functioning. Younger age, male sex, higher education, higher mastery, smoking and alcohol use, higher physical activity levels, absence of chronic diseases, and more contacts with friends predicted resilience in one or more domains of functioning. Conclusions: Few people with LLOA and persistent severe pain showed good physical functioning and about half showed good mental or social functioning. Predictors of resilience differed between domains, and might provide new insights for treatment.",

keywords = "Older Adults, Osteoarthritis, Pain, Predictors, Resilience",

author = "{van Schoor}, {Natasja M.} and Timmermans, {Erik J.} and Martijn Huisman and Alicia Guti{\'e}rrez-Misis and Willem Lems and Dennison, {Elaine M.} and Castell, {Maria Victoria} and Denkinger, {Michael D.} and Pedersen, {Nancy L.} and Stefania Maggi and Deeg, {Dorly J.H.}",

note = "Funding Information: The Indicators for Monitoring COPD and Asthma—Activity and Function in the Elderly in Ulm study (IMCA—ActiFE) was supported by the European Union (grant number 2005121) and the Ministry of Science, Baden-W{\"u}rttemberg. The Italian cohort was supported by the National Research Council of Italy (CNR), Research Project “Aging: molecular and technological innovations for improving the health of the elderly population” (Prot. MIUR 2867). The Longitudinal Aging Study Amsterdam (LASA) is financially supported by the Dutch Ministry of Health, Welfare and Sports (grant number 311669). The Pe{\~n}agrande study was partially supported by the National Fund for Health Research (Fondo de Investigaciones en Salud) of Spain (grant numbers FIS PI 05/1898, FIS RETICEF RD06/0013/1013, FIS PS09/02143). The Swedish Twin Registry is managed by Karolinska Institutet and receives funding through the Swedish Research Council (grant number 2017–00641). The Hertfordshire Cohort Study is supported by the Medical Research Council of Great Britain, Versus Arthritis, the British Heart Foundation and the International Osteoporosis Foundation (grant number MRC_MC_UP_A620_1014). The funders were not involved in the study design, data collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

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doi = "10.1186/s12877-022-02926-7",

language = "English",

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journal = "BMC Geriatrics",

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AU - van Schoor, Natasja M.

AU - Timmermans, Erik J.

AU - Huisman, Martijn

AU - Gutiérrez-Misis, Alicia

AU - Lems, Willem

AU - Dennison, Elaine M.

AU - Castell, Maria Victoria

AU - Denkinger, Michael D.

AU - Pedersen, Nancy L.

AU - Maggi, Stefania

AU - Deeg, Dorly J.H.

N1 - Funding Information: The Indicators for Monitoring COPD and Asthma—Activity and Function in the Elderly in Ulm study (IMCA—ActiFE) was supported by the European Union (grant number 2005121) and the Ministry of Science, Baden-Württemberg. The Italian cohort was supported by the National Research Council of Italy (CNR), Research Project “Aging: molecular and technological innovations for improving the health of the elderly population” (Prot. MIUR 2867). The Longitudinal Aging Study Amsterdam (LASA) is financially supported by the Dutch Ministry of Health, Welfare and Sports (grant number 311669). The Peñagrande study was partially supported by the National Fund for Health Research (Fondo de Investigaciones en Salud) of Spain (grant numbers FIS PI 05/1898, FIS RETICEF RD06/0013/1013, FIS PS09/02143). The Swedish Twin Registry is managed by Karolinska Institutet and receives funding through the Swedish Research Council (grant number 2017–00641). The Hertfordshire Cohort Study is supported by the Medical Research Council of Great Britain, Versus Arthritis, the British Heart Foundation and the International Osteoporosis Foundation (grant number MRC_MC_UP_A620_1014). The funders were not involved in the study design, data collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. Publisher Copyright: © 2022, The Author(s).

PY - 2022/3/24

Y1 - 2022/3/24

N2 - Background: Resilience refers to the process in which people function well despite adversity. Persistent severe pain may be considered an adversity in people with lower limb osteoarthritis (LLOA). The objectives of this study are: (1) to identify what proportion of older adults with LLOA and persistent severe pain show good functioning; and (2) to explore predictors of resilience. Methods: Data from the European Project on OSteoArthritis (EPOSA) were used involving standardized data from six European population-based cohort studies. LLOA is defined as clinical knee and/or hip osteoarthritis. Persistent severe pain is defined as the highest tertile of the pain subscale of the Western Ontario and McMaster Universities Osteoarthritis Index both at baseline and follow-up. Resilience is defined as good physical, mental or social functioning at follow-up despite having LLOA with persistent severe pain. Results: In total, 95 (14.9%) out of 638 individuals with LLOA had persistent severe pain. Among these, 10 (11.0%), 54 (57.4%) and 49 (53.8%) had good physical, mental and social functioning, respectively. Only 4 individuals (4.5%) were resilient in all three domains of functioning. Younger age, male sex, higher education, higher mastery, smoking and alcohol use, higher physical activity levels, absence of chronic diseases, and more contacts with friends predicted resilience in one or more domains of functioning. Conclusions: Few people with LLOA and persistent severe pain showed good physical functioning and about half showed good mental or social functioning. Predictors of resilience differed between domains, and might provide new insights for treatment.

AB - Background: Resilience refers to the process in which people function well despite adversity. Persistent severe pain may be considered an adversity in people with lower limb osteoarthritis (LLOA). The objectives of this study are: (1) to identify what proportion of older adults with LLOA and persistent severe pain show good functioning; and (2) to explore predictors of resilience. Methods: Data from the European Project on OSteoArthritis (EPOSA) were used involving standardized data from six European population-based cohort studies. LLOA is defined as clinical knee and/or hip osteoarthritis. Persistent severe pain is defined as the highest tertile of the pain subscale of the Western Ontario and McMaster Universities Osteoarthritis Index both at baseline and follow-up. Resilience is defined as good physical, mental or social functioning at follow-up despite having LLOA with persistent severe pain. Results: In total, 95 (14.9%) out of 638 individuals with LLOA had persistent severe pain. Among these, 10 (11.0%), 54 (57.4%) and 49 (53.8%) had good physical, mental and social functioning, respectively. Only 4 individuals (4.5%) were resilient in all three domains of functioning. Younger age, male sex, higher education, higher mastery, smoking and alcohol use, higher physical activity levels, absence of chronic diseases, and more contacts with friends predicted resilience in one or more domains of functioning. Conclusions: Few people with LLOA and persistent severe pain showed good physical functioning and about half showed good mental or social functioning. Predictors of resilience differed between domains, and might provide new insights for treatment.

KW - Older Adults

KW - Osteoarthritis

KW - Pain

KW - Predictors

KW - Resilience

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Predictors of resilience in older adults with lower limb osteoarthritis and persistent severe pain

Abstract

Bibliographical note

Funding

Keywords

Access to Document

Persistent URL (handle)

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Longitudinal Aging Study Amsterdam

Cite this

Predictors of resilience in older adults with lower limb osteoarthritis and persistent severe pain

Abstract

Bibliographical note

Funding

Keywords

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Datasets

Longitudinal Aging Study Amsterdam

Cite this