Prenatal exposure to endocrine disrupting chemicals and birth weight – a prospective cohort study

M. de Cock, M.R. de Boer, M. Lamoree, J. Legler, M. van de Bor

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Prenatal exposure to endocrine disrupting chemicals may affect fetal development through disruption of hormonal actions and epigenetic modifications, potentially predisposing individuals to later on-set health risks, such as obesity. The objective of this study was to determine associations between biological exposure markers of various endocrine disrupting chemicals and birth weight in a newly established, prospective mother-child cohort in the Netherlands. Birth weight (n = 91) was obtained from birth records, and exposure to dichlorodiphenyldichloroethylene (DDE), three di-2-ethylhexyl phthalate (DEHP) metabolites, polychlorinated biphenyl-153, perfluorooctanesulfonic acid (PFOS), and perfluorooctanoic acid (PFOA) was determined in cord plasma. For DDE, exposure was also measured in breast milk. Linear regression analysis was used to determine associations between compounds and birth weight, which were stratified for gender and adjusted for a priori defined covariates. Increased exposure to DDE was associated with lower birth weight in boys (>95.89 ng L
Original languageEnglish
Pages (from-to)178-185
JournalJournal of Environmental Science and Health
Volume51
Issue number2
Early online date25 Nov 2015
DOIs
Publication statusPublished - 2016

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Acids
Health risks
Metabolites
Polychlorinated biphenyls
Linear regression
Regression analysis
Plasmas
Human Milk

Cite this

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title = "Prenatal exposure to endocrine disrupting chemicals and birth weight – a prospective cohort study",
abstract = "Prenatal exposure to endocrine disrupting chemicals may affect fetal development through disruption of hormonal actions and epigenetic modifications, potentially predisposing individuals to later on-set health risks, such as obesity. The objective of this study was to determine associations between biological exposure markers of various endocrine disrupting chemicals and birth weight in a newly established, prospective mother-child cohort in the Netherlands. Birth weight (n = 91) was obtained from birth records, and exposure to dichlorodiphenyldichloroethylene (DDE), three di-2-ethylhexyl phthalate (DEHP) metabolites, polychlorinated biphenyl-153, perfluorooctanesulfonic acid (PFOS), and perfluorooctanoic acid (PFOA) was determined in cord plasma. For DDE, exposure was also measured in breast milk. Linear regression analysis was used to determine associations between compounds and birth weight, which were stratified for gender and adjusted for a priori defined covariates. Increased exposure to DDE was associated with lower birth weight in boys (>95.89 ng L",
author = "{de Cock}, M. and {de Boer}, M.R. and M. Lamoree and J. Legler and {van de Bor}, M.",
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Prenatal exposure to endocrine disrupting chemicals and birth weight – a prospective cohort study. / de Cock, M.; de Boer, M.R.; Lamoree, M.; Legler, J.; van de Bor, M.

In: Journal of Environmental Science and Health, Vol. 51, No. 2, 2016, p. 178-185.

Research output: Contribution to JournalArticleAcademicpeer-review

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