Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: A prospective cohort study

Hilde B. Lauritzen; Tricia L. Larose; Torbjørn Øien; Torkjel M. Sandanger; Jon O. Odland; Margot Van De Bor; Geir W. Jacobsen

doi:10.1186/s12940-017-0338-x

Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: A prospective cohort study

Hilde B. Lauritzen^*
, Tricia L. Larose
, Torbjørn Øien
, Torkjel M. Sandanger
, Jon O. Odland
, Margot Van De Bor
, Geir W. Jacobsen

^*Corresponding author for this work

AIMMS

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Prenatal exposure to persistent organic pollutants (POPs), may influence offspring weight gain. More prospective epidemiological studies are needed to compliment the growing body of evidence from animal studies. Methods: Serum from 412 pregnant Norwegian and Swedish women participating in a Scandinavian prospective cohort study were collected in 1986-88, and analyses of two perfluoroalkyl substances (PFASs) and five organochlorines (OCs) were conducted. We used linear and logistic regression models with 95% confidence intervals (CIs) to evaluate the associations between maternal serum POP concentrations at 17-20 weeks of gestation and child overweight/obesity (body mass index (BMI) ≥ 85th percentile) at 5-year follow-up. Results were further stratified by country after testing for effect modification. We also assessed potential non-monotonic dose-response (NMDR) relationships. Results: In adjusted linear models, we observed increased BMI-for-age-and-sex z-score (β = 0.18, 95% CI: 0.01-0.35), and increased triceps skinfold z-score (β = 0.15, 95% CI: 0.02-0.27) in children at 5-year follow-up per ln-unit increase in maternal serum perfluorooctane sulfonate (PFOS) concentrations. We observed increased odds for child overweight/obesity (BMI ≥ 85th percentile) for each ln-unit increase in maternal serum PFOS levels (adjusted OR: 2.04, 95% CI: 1.11-3.74), with stronger odds among Norwegian children (OR: 2.96, 95% CI: 1.42-6.15). We found similar associations between maternal serum perfluorooctanoate (PFOA) concentrations and child overweight/obesity. We found indications of NMDR relationships between PFOS and polychlorinated biphenyl (PCB) 153 and child overweight/obesity among Swedish children. Conclusion: We found positive associations between maternal serum PFAS concentrations and child overweight/obesity at 5-year follow-up, particularly among Norwegian participants. We observed some evidence for NMDR relationships among Swedish participants.

Original language	English
Article number	9
Pages (from-to)	1-12
Number of pages	12
Journal	Environmental Health: A Global Access Science Source
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s12940-017-0338-x
Publication status	Published - 18 Jan 2018

Funding

All participants provided written informed consent for continued use of data and biomaterial, which was documented at the first study visit. The study, including the consent procedure, has been reviewed and approved by the Central Norway Regional Committee for Medical and Health Sciences Research Ethics (REK Midt 2010/1449–5). This work was funded by grants from the Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Funders	Funder number
Central Norway Regional Committee for Medical and Health Sciences Research Ethics
Liaison Committee
Respiratory Health Association
Norges Teknisk-Naturvitenskapelige Universitet	NTNU
Helse Midt-Norge

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Childhood obesity
Endocrine disrupting chemicals
Non-monotonic dose-response relationship
Organochlorines
Perfluoroalkyl substances
Pregnancy
Skinfolds

Access to Document

10.1186/s12940-017-0338-x

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Cite this

@article{854ecc1c8a7749a5b7e77f79eb681221,

title = "Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: A prospective cohort study",

abstract = "Background: Prenatal exposure to persistent organic pollutants (POPs), may influence offspring weight gain. More prospective epidemiological studies are needed to compliment the growing body of evidence from animal studies. Methods: Serum from 412 pregnant Norwegian and Swedish women participating in a Scandinavian prospective cohort study were collected in 1986-88, and analyses of two perfluoroalkyl substances (PFASs) and five organochlorines (OCs) were conducted. We used linear and logistic regression models with 95\% confidence intervals (CIs) to evaluate the associations between maternal serum POP concentrations at 17-20 weeks of gestation and child overweight/obesity (body mass index (BMI) ≥ 85th percentile) at 5-year follow-up. Results were further stratified by country after testing for effect modification. We also assessed potential non-monotonic dose-response (NMDR) relationships. Results: In adjusted linear models, we observed increased BMI-for-age-and-sex z-score (β = 0.18, 95\% CI: 0.01-0.35), and increased triceps skinfold z-score (β = 0.15, 95\% CI: 0.02-0.27) in children at 5-year follow-up per ln-unit increase in maternal serum perfluorooctane sulfonate (PFOS) concentrations. We observed increased odds for child overweight/obesity (BMI ≥ 85th percentile) for each ln-unit increase in maternal serum PFOS levels (adjusted OR: 2.04, 95\% CI: 1.11-3.74), with stronger odds among Norwegian children (OR: 2.96, 95\% CI: 1.42-6.15). We found similar associations between maternal serum perfluorooctanoate (PFOA) concentrations and child overweight/obesity. We found indications of NMDR relationships between PFOS and polychlorinated biphenyl (PCB) 153 and child overweight/obesity among Swedish children. Conclusion: We found positive associations between maternal serum PFAS concentrations and child overweight/obesity at 5-year follow-up, particularly among Norwegian participants. We observed some evidence for NMDR relationships among Swedish participants.",

keywords = "Childhood obesity, Endocrine disrupting chemicals, Non-monotonic dose-response relationship, Organochlorines, Perfluoroalkyl substances, Pregnancy, Skinfolds",

author = "Lauritzen, \{Hilde B.\} and Larose, \{Tricia L.\} and Torbj{\o}rn {\O}ien and Sandanger, \{Torkjel M.\} and Odland, \{Jon O.\} and \{Van De Bor\}, Margot and Jacobsen, \{Geir W.\}",

year = "2018",

month = jan,

day = "18",

doi = "10.1186/s12940-017-0338-x",

language = "English",

volume = "17",

pages = "1--12",

journal = "Environmental Health: A Global Access Science Source",

issn = "1476-069X",

publisher = "BioMed Central Ltd",

number = "1",

}

Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: A prospective cohort study. / Lauritzen, Hilde B.; Larose, Tricia L.; Øien, Torbjørn et al.
In: Environmental Health: A Global Access Science Source, Vol. 17, No. 1, 9, 18.01.2018, p. 1-12.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up

T2 - A prospective cohort study

AU - Lauritzen, Hilde B.

AU - Larose, Tricia L.

AU - Øien, Torbjørn

AU - Sandanger, Torkjel M.

AU - Odland, Jon O.

AU - Van De Bor, Margot

AU - Jacobsen, Geir W.

PY - 2018/1/18

Y1 - 2018/1/18

N2 - Background: Prenatal exposure to persistent organic pollutants (POPs), may influence offspring weight gain. More prospective epidemiological studies are needed to compliment the growing body of evidence from animal studies. Methods: Serum from 412 pregnant Norwegian and Swedish women participating in a Scandinavian prospective cohort study were collected in 1986-88, and analyses of two perfluoroalkyl substances (PFASs) and five organochlorines (OCs) were conducted. We used linear and logistic regression models with 95% confidence intervals (CIs) to evaluate the associations between maternal serum POP concentrations at 17-20 weeks of gestation and child overweight/obesity (body mass index (BMI) ≥ 85th percentile) at 5-year follow-up. Results were further stratified by country after testing for effect modification. We also assessed potential non-monotonic dose-response (NMDR) relationships. Results: In adjusted linear models, we observed increased BMI-for-age-and-sex z-score (β = 0.18, 95% CI: 0.01-0.35), and increased triceps skinfold z-score (β = 0.15, 95% CI: 0.02-0.27) in children at 5-year follow-up per ln-unit increase in maternal serum perfluorooctane sulfonate (PFOS) concentrations. We observed increased odds for child overweight/obesity (BMI ≥ 85th percentile) for each ln-unit increase in maternal serum PFOS levels (adjusted OR: 2.04, 95% CI: 1.11-3.74), with stronger odds among Norwegian children (OR: 2.96, 95% CI: 1.42-6.15). We found similar associations between maternal serum perfluorooctanoate (PFOA) concentrations and child overweight/obesity. We found indications of NMDR relationships between PFOS and polychlorinated biphenyl (PCB) 153 and child overweight/obesity among Swedish children. Conclusion: We found positive associations between maternal serum PFAS concentrations and child overweight/obesity at 5-year follow-up, particularly among Norwegian participants. We observed some evidence for NMDR relationships among Swedish participants.

AB - Background: Prenatal exposure to persistent organic pollutants (POPs), may influence offspring weight gain. More prospective epidemiological studies are needed to compliment the growing body of evidence from animal studies. Methods: Serum from 412 pregnant Norwegian and Swedish women participating in a Scandinavian prospective cohort study were collected in 1986-88, and analyses of two perfluoroalkyl substances (PFASs) and five organochlorines (OCs) were conducted. We used linear and logistic regression models with 95% confidence intervals (CIs) to evaluate the associations between maternal serum POP concentrations at 17-20 weeks of gestation and child overweight/obesity (body mass index (BMI) ≥ 85th percentile) at 5-year follow-up. Results were further stratified by country after testing for effect modification. We also assessed potential non-monotonic dose-response (NMDR) relationships. Results: In adjusted linear models, we observed increased BMI-for-age-and-sex z-score (β = 0.18, 95% CI: 0.01-0.35), and increased triceps skinfold z-score (β = 0.15, 95% CI: 0.02-0.27) in children at 5-year follow-up per ln-unit increase in maternal serum perfluorooctane sulfonate (PFOS) concentrations. We observed increased odds for child overweight/obesity (BMI ≥ 85th percentile) for each ln-unit increase in maternal serum PFOS levels (adjusted OR: 2.04, 95% CI: 1.11-3.74), with stronger odds among Norwegian children (OR: 2.96, 95% CI: 1.42-6.15). We found similar associations between maternal serum perfluorooctanoate (PFOA) concentrations and child overweight/obesity. We found indications of NMDR relationships between PFOS and polychlorinated biphenyl (PCB) 153 and child overweight/obesity among Swedish children. Conclusion: We found positive associations between maternal serum PFAS concentrations and child overweight/obesity at 5-year follow-up, particularly among Norwegian participants. We observed some evidence for NMDR relationships among Swedish participants.

KW - Childhood obesity

KW - Endocrine disrupting chemicals

KW - Non-monotonic dose-response relationship

KW - Organochlorines

KW - Perfluoroalkyl substances

KW - Pregnancy

KW - Skinfolds

UR - https://www.scopus.com/pages/publications/85040811030

UR - https://www.scopus.com/pages/publications/85040811030#tab=citedBy

U2 - 10.1186/s12940-017-0338-x

DO - 10.1186/s12940-017-0338-x

M3 - Article

AN - SCOPUS:85040811030

SN - 1476-069X

VL - 17

SP - 1

EP - 12

JO - Environmental Health: A Global Access Science Source

JF - Environmental Health: A Global Access Science Source

IS - 1

M1 - 9

ER -

Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: A prospective cohort study

Abstract

Funding

UN SDGs

Keywords

Access to Document

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