Presynaptic signal transduction pathways that modulate synaptic transmission

A.P.H. de Jong; M. Verhage

doi:10.1016/j.conb.2009.06.005

Presynaptic signal transduction pathways that modulate synaptic transmission

A.P.H. de Jong, M. Verhage

Functional Genomics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Presynaptic modulation is a crucial factor in the adaptive capacity of the nervous system. The coupling between incoming action potentials and neurotransmitter secretion is modulated by firstly, recent activity of the presynaptic axon that leads to the accumulation of residual calcium in the terminal and secondly, activation of presynaptic receptors by external signals. Despite the detailed description of these phenomena, the underlying mechanisms are still poorly understood. The nerve terminal contains many Ca

Original language	English
Pages (from-to)	245-253
Number of pages	8
Journal	Current Opinion in Neurobiology
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/j.conb.2009.06.005
Publication status	Published - 2009

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title = "Presynaptic signal transduction pathways that modulate synaptic transmission",

abstract = "Presynaptic modulation is a crucial factor in the adaptive capacity of the nervous system. The coupling between incoming action potentials and neurotransmitter secretion is modulated by firstly, recent activity of the presynaptic axon that leads to the accumulation of residual calcium in the terminal and secondly, activation of presynaptic receptors by external signals. Despite the detailed description of these phenomena, the underlying mechanisms are still poorly understood. The nerve terminal contains many Ca",

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AU - Verhage, M.

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AB - Presynaptic modulation is a crucial factor in the adaptive capacity of the nervous system. The coupling between incoming action potentials and neurotransmitter secretion is modulated by firstly, recent activity of the presynaptic axon that leads to the accumulation of residual calcium in the terminal and secondly, activation of presynaptic receptors by external signals. Despite the detailed description of these phenomena, the underlying mechanisms are still poorly understood. The nerve terminal contains many Ca

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DO - 10.1016/j.conb.2009.06.005

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EP - 253

JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

SN - 0959-4388

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ER -

Presynaptic signal transduction pathways that modulate synaptic transmission

Abstract

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