Presynaptic signal transduction pathways that modulate synaptic transmission

A.P.H. de Jong, M. Verhage

Research output: Contribution to JournalArticleAcademicpeer-review


Presynaptic modulation is a crucial factor in the adaptive capacity of the nervous system. The coupling between incoming action potentials and neurotransmitter secretion is modulated by firstly, recent activity of the presynaptic axon that leads to the accumulation of residual calcium in the terminal and secondly, activation of presynaptic receptors by external signals. Despite the detailed description of these phenomena, the underlying mechanisms are still poorly understood. The nerve terminal contains many Ca
Original languageEnglish
Pages (from-to)245-253
Number of pages8
JournalCurrent Opinion in Neurobiology
Issue number3
Publication statusPublished - 2009


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