Prevalence of sarcopenia as a comorbid disease: A systematic review and meta-analysis

Jacob Pacifico, Milou A J Geerlings, Esmee M Reijnierse, Christina Phassouliotis, Wen Kwang Lim, Andrea B Maier

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

Background: Sarcopenia shares risk factors with various other age-related diseases. This meta-analysis aimed to determine the prevalence of sarcopenia as a comorbid disease. Methods: Medline, EMBASE and Cochrane databases were searched for articles from inception to 8th June 2018, reporting the prevalence of sarcopenia in individuals with a diagnosis of cardiovascular disease (CVD), dementia, diabetes mellitus or respiratory disease and, if applicable their controls. No exclusion criteria were applied with regards to definition of sarcopenia, individuals' age, study design and setting. Meta-analyses were stratified by disease, definition of sarcopenia and continent. Results: The 63 included articles described 17,206 diseased individuals (mean age: 65.3 ± 1.6 years, 49.9% females) and 22,375 non-diseased controls (mean age: 54.6 ± 16.2 years, 53.8% females). The prevalence of sarcopenia in individuals with CVD was 31.4% (95% CI: 22.4–42.1%), no controls were available. The prevalence of sarcopenia was 26.4% (95% CI: 13.6–44.8%) in individuals with dementia compared to 8.3% (95% CI: 2.8–21.9%) in their controls; 31.1% (95% CI: 19.8–45.2%) in individuals with diabetes mellitus compared to 16.2% (95% CI: 9.5–26.2%) in controls; and 26.8% (95% CI: 17.8–38.1%) in individuals with respiratory diseases compared to 13.3% (95% CI: 8.3–20.7%) in controls. Conclusions: Sarcopenia is highly prevalent in individuals with CVD, dementia, diabetes mellitus and respiratory disease.

Original languageEnglish
Article number110801
Pages (from-to)1-19
Number of pages19
JournalExperimental Gerontology
Volume131
Early online date28 Dec 2019
DOIs
Publication statusE-pub ahead of print - 28 Dec 2019

Fingerprint

Sarcopenia
Meta-Analysis
Pulmonary diseases
Medical problems
Dementia
Diabetes Mellitus
Cardiovascular Diseases
Databases

Bibliographical note

Copyright © 2019. Published by Elsevier Inc.

Keywords

  • Aged
  • Cardiovascular diseases
  • Dementia
  • Diabetes mellitus
  • Respiratory tract diseases
  • Sarcopenia

Cite this

Pacifico, Jacob ; Geerlings, Milou A J ; Reijnierse, Esmee M ; Phassouliotis, Christina ; Lim, Wen Kwang ; Maier, Andrea B. / Prevalence of sarcopenia as a comorbid disease : A systematic review and meta-analysis. In: Experimental Gerontology. 2020 ; Vol. 131. pp. 1-19.
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abstract = "Background: Sarcopenia shares risk factors with various other age-related diseases. This meta-analysis aimed to determine the prevalence of sarcopenia as a comorbid disease. Methods: Medline, EMBASE and Cochrane databases were searched for articles from inception to 8th June 2018, reporting the prevalence of sarcopenia in individuals with a diagnosis of cardiovascular disease (CVD), dementia, diabetes mellitus or respiratory disease and, if applicable their controls. No exclusion criteria were applied with regards to definition of sarcopenia, individuals' age, study design and setting. Meta-analyses were stratified by disease, definition of sarcopenia and continent. Results: The 63 included articles described 17,206 diseased individuals (mean age: 65.3 ± 1.6 years, 49.9{\%} females) and 22,375 non-diseased controls (mean age: 54.6 ± 16.2 years, 53.8{\%} females). The prevalence of sarcopenia in individuals with CVD was 31.4{\%} (95{\%} CI: 22.4–42.1{\%}), no controls were available. The prevalence of sarcopenia was 26.4{\%} (95{\%} CI: 13.6–44.8{\%}) in individuals with dementia compared to 8.3{\%} (95{\%} CI: 2.8–21.9{\%}) in their controls; 31.1{\%} (95{\%} CI: 19.8–45.2{\%}) in individuals with diabetes mellitus compared to 16.2{\%} (95{\%} CI: 9.5–26.2{\%}) in controls; and 26.8{\%} (95{\%} CI: 17.8–38.1{\%}) in individuals with respiratory diseases compared to 13.3{\%} (95{\%} CI: 8.3–20.7{\%}) in controls. Conclusions: Sarcopenia is highly prevalent in individuals with CVD, dementia, diabetes mellitus and respiratory disease.",
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author = "Jacob Pacifico and Geerlings, {Milou A J} and Reijnierse, {Esmee M} and Christina Phassouliotis and Lim, {Wen Kwang} and Maier, {Andrea B}",
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Prevalence of sarcopenia as a comorbid disease : A systematic review and meta-analysis. / Pacifico, Jacob; Geerlings, Milou A J; Reijnierse, Esmee M; Phassouliotis, Christina; Lim, Wen Kwang; Maier, Andrea B.

In: Experimental Gerontology, Vol. 131, 110801, 01.03.2020, p. 1-19.

Research output: Contribution to JournalReview articleAcademicpeer-review

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T1 - Prevalence of sarcopenia as a comorbid disease

T2 - A systematic review and meta-analysis

AU - Pacifico, Jacob

AU - Geerlings, Milou A J

AU - Reijnierse, Esmee M

AU - Phassouliotis, Christina

AU - Lim, Wen Kwang

AU - Maier, Andrea B

N1 - Copyright © 2019. Published by Elsevier Inc.

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N2 - Background: Sarcopenia shares risk factors with various other age-related diseases. This meta-analysis aimed to determine the prevalence of sarcopenia as a comorbid disease. Methods: Medline, EMBASE and Cochrane databases were searched for articles from inception to 8th June 2018, reporting the prevalence of sarcopenia in individuals with a diagnosis of cardiovascular disease (CVD), dementia, diabetes mellitus or respiratory disease and, if applicable their controls. No exclusion criteria were applied with regards to definition of sarcopenia, individuals' age, study design and setting. Meta-analyses were stratified by disease, definition of sarcopenia and continent. Results: The 63 included articles described 17,206 diseased individuals (mean age: 65.3 ± 1.6 years, 49.9% females) and 22,375 non-diseased controls (mean age: 54.6 ± 16.2 years, 53.8% females). The prevalence of sarcopenia in individuals with CVD was 31.4% (95% CI: 22.4–42.1%), no controls were available. The prevalence of sarcopenia was 26.4% (95% CI: 13.6–44.8%) in individuals with dementia compared to 8.3% (95% CI: 2.8–21.9%) in their controls; 31.1% (95% CI: 19.8–45.2%) in individuals with diabetes mellitus compared to 16.2% (95% CI: 9.5–26.2%) in controls; and 26.8% (95% CI: 17.8–38.1%) in individuals with respiratory diseases compared to 13.3% (95% CI: 8.3–20.7%) in controls. Conclusions: Sarcopenia is highly prevalent in individuals with CVD, dementia, diabetes mellitus and respiratory disease.

AB - Background: Sarcopenia shares risk factors with various other age-related diseases. This meta-analysis aimed to determine the prevalence of sarcopenia as a comorbid disease. Methods: Medline, EMBASE and Cochrane databases were searched for articles from inception to 8th June 2018, reporting the prevalence of sarcopenia in individuals with a diagnosis of cardiovascular disease (CVD), dementia, diabetes mellitus or respiratory disease and, if applicable their controls. No exclusion criteria were applied with regards to definition of sarcopenia, individuals' age, study design and setting. Meta-analyses were stratified by disease, definition of sarcopenia and continent. Results: The 63 included articles described 17,206 diseased individuals (mean age: 65.3 ± 1.6 years, 49.9% females) and 22,375 non-diseased controls (mean age: 54.6 ± 16.2 years, 53.8% females). The prevalence of sarcopenia in individuals with CVD was 31.4% (95% CI: 22.4–42.1%), no controls were available. The prevalence of sarcopenia was 26.4% (95% CI: 13.6–44.8%) in individuals with dementia compared to 8.3% (95% CI: 2.8–21.9%) in their controls; 31.1% (95% CI: 19.8–45.2%) in individuals with diabetes mellitus compared to 16.2% (95% CI: 9.5–26.2%) in controls; and 26.8% (95% CI: 17.8–38.1%) in individuals with respiratory diseases compared to 13.3% (95% CI: 8.3–20.7%) in controls. Conclusions: Sarcopenia is highly prevalent in individuals with CVD, dementia, diabetes mellitus and respiratory disease.

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KW - Cardiovascular diseases

KW - Dementia

KW - Diabetes mellitus

KW - Respiratory tract diseases

KW - Sarcopenia

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