Principles of pharmacology and toxicology also govern effects of chemicals on the endocrine system

Herman Autrup, Frank A. Barile, Bas J. Blaauboer, Gisela H. Degen, Wolfgang Dekant*, Daniel Dietrich, Jose L. Domingo, Gio Batta Gori, Helmuth Greim, Jan G. Hengstler, Sam Kacew, Hans Marquardt, Olavi Pelkonen, Kai Savolainen, Nico P. Vermeulen

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The present debate on chemicals with Hormonal activity, often termed 'endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.

Original languageEnglish
Article numberkfv082
Pages (from-to)11-15
Number of pages5
JournalToxicological Sciences
Volume146
Issue number1
DOIs
Publication statusPublished - 1 Jul 2015

Keywords

  • Endocrine disruptors
  • Endocrine toxicology
  • Regulatory/policy
  • Risk assessment

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