TY - JOUR
T1 - Probability effects in the stop-signal paradigm
T2 - The insula and the significance of failed inhibition
AU - Ramautar, Jennifer R.
AU - Slagter, Heleen A.
AU - Kok, Albert
AU - Ridderinkhof, K. Richard
PY - 2006/8/11
Y1 - 2006/8/11
N2 - In the present randomized, mixed-trial event-related fMRI study, we examined the neural mechanisms underlying inhibitory control using a stop-signal paradigm in which stop-signal frequency was manipulated parametrically across blocks. As hypothesized, presenting stop signals less frequently was accompanied by a stronger set to respond to the go stimuli as subjects were faster in responding to go stimuli on no stop-signal trials and made more commission errors (i.e., were less successful in inhibiting the go response) on stop-signal trials. When response inhibition was successful, having to inhibit responses more frequently compared to less frequently was associated with greater activation in occipital areas. This presumably reflects enhanced visual attention to the stop signal. When response inhibition failed, greater activity was observed in bilateral insula when stop signals were presented less compared to more frequently. The insula may thus play a role in processing the significance of inhibitory failure.
AB - In the present randomized, mixed-trial event-related fMRI study, we examined the neural mechanisms underlying inhibitory control using a stop-signal paradigm in which stop-signal frequency was manipulated parametrically across blocks. As hypothesized, presenting stop signals less frequently was accompanied by a stronger set to respond to the go stimuli as subjects were faster in responding to go stimuli on no stop-signal trials and made more commission errors (i.e., were less successful in inhibiting the go response) on stop-signal trials. When response inhibition was successful, having to inhibit responses more frequently compared to less frequently was associated with greater activation in occipital areas. This presumably reflects enhanced visual attention to the stop signal. When response inhibition failed, greater activity was observed in bilateral insula when stop signals were presented less compared to more frequently. The insula may thus play a role in processing the significance of inhibitory failure.
KW - Event-related fMRI
KW - Failed inhibition
KW - Inhibitory control
KW - Insula
KW - Probability effect
KW - Stop-signal paradigm
UR - http://www.scopus.com/inward/record.url?scp=33746858126&partnerID=8YFLogxK
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U2 - 10.1016/j.brainres.2006.02.091
DO - 10.1016/j.brainres.2006.02.091
M3 - Article
C2 - 16616048
AN - SCOPUS:33746858126
VL - 1105
SP - 143
EP - 154
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -