Probiotics for improving quality of life in ulcerative colitis: Exploring the patient perspective

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Ulcerative colitis (UC) is known to burden patients in ways that are not always clinically apparent and therefore easily overlooked in conventional treatment regimens. The medical needs of UC patients thus may be unmet, calling for novel patient-centered approaches to alleviate disease impact and improve quality of life (QoL). Probiotics are suggested as a safe and effective addition to current regimens, but the clinical evidence base appears insufficient to support efficacy verdicts. This study therefore qualitatively explored UC's impact on QoL from a patient perspective, and evaluated the potential of a multispecies probiotic for impact alleviation. Semi-structured interviews were held with 23 UC patients, who had either opted for a trial period with the multispecies probiotic Ecologic® 825 (n=14) or had not (n=9). The thematic analysis elucidates the broad nature of UC's impact, identifying 5 core impact domains and effects throughout. Furthermore, as patients’ attitudes towards probiotics were predominantly positive, 57% of users reported positive impact of consumption, and the vast majority of these deemed this as (highly) relevant for improving QoL, the findings favor probiotic supplementation and warrant further clinical evaluation. In this regard, defecation frequency and stool texture seem promising outcome parameters for being most often reported.

Original languageEnglish
Article number100139
Pages (from-to)1-14
Number of pages14
JournalPharmaNutrition
Volume7
Early online date15 Nov 2018
DOIs
Publication statusPublished - Mar 2019

Fingerprint

colitis
Probiotics
quality of life
Ulcerative Colitis
probiotics
Quality of Life
Defecation
defecation
interviews
texture
Interviews

Keywords

  • Multispecies
  • Patient-centered care
  • Patient-reported outcome
  • Probiotics
  • Quality of life
  • Ulcerative colitis

Cite this

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title = "Probiotics for improving quality of life in ulcerative colitis: Exploring the patient perspective",
abstract = "Ulcerative colitis (UC) is known to burden patients in ways that are not always clinically apparent and therefore easily overlooked in conventional treatment regimens. The medical needs of UC patients thus may be unmet, calling for novel patient-centered approaches to alleviate disease impact and improve quality of life (QoL). Probiotics are suggested as a safe and effective addition to current regimens, but the clinical evidence base appears insufficient to support efficacy verdicts. This study therefore qualitatively explored UC's impact on QoL from a patient perspective, and evaluated the potential of a multispecies probiotic for impact alleviation. Semi-structured interviews were held with 23 UC patients, who had either opted for a trial period with the multispecies probiotic Ecologic{\circledR} 825 (n=14) or had not (n=9). The thematic analysis elucidates the broad nature of UC's impact, identifying 5 core impact domains and effects throughout. Furthermore, as patients’ attitudes towards probiotics were predominantly positive, 57{\%} of users reported positive impact of consumption, and the vast majority of these deemed this as (highly) relevant for improving QoL, the findings favor probiotic supplementation and warrant further clinical evaluation. In this regard, defecation frequency and stool texture seem promising outcome parameters for being most often reported.",
keywords = "Multispecies, Patient-centered care, Patient-reported outcome, Probiotics, Quality of life, Ulcerative colitis",
author = "{van der Waal}, {Mark B.} and Joost Flach and Browne, {Pamela D.} and {Besseling-van der Vaart}, Isolde and Eric Claassen and {van de Burgwal}, {Linda H.M.}",
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Probiotics for improving quality of life in ulcerative colitis : Exploring the patient perspective. / van der Waal, Mark B.; Flach, Joost; Browne, Pamela D.; Besseling-van der Vaart, Isolde; Claassen, Eric; van de Burgwal, Linda H.M.

In: PharmaNutrition, Vol. 7, 100139, 03.2019, p. 1-14.

Research output: Contribution to JournalArticleAcademicpeer-review

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AU - Flach, Joost

AU - Browne, Pamela D.

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