Abstract
Understanding the healthy and diseased state of skin is important in many areas of basic and applied research. Although the field of skin tissue engineering has advanced greatly over the last years, current in vitro skin models still do not mimic the complexity of the human skin. Skin-on-chip and induced pluripotent stem cells (iPSC) might be key technologies to improve in vitro skin models. This review summarizes the state of the art of in vitro skin models with regard to cell sources (primary, cell line, iPSC) and microfluidic devices. It can be concluded that iPSC have the potential to be differentiated into many kinds of immunologically matched cells and skin-on-chip technology might lead to more physiologically relevant skin models due to the controlled environment, possible exchange of immune cells, and an increased barrier function. Therefore the combination of iPSC and skin-on-chip is expected to lead to superior healthy and diseased in vitro skin models.
Original language | English |
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Pages (from-to) | 418-429 |
Journal | Stem cell reviews and reports |
Volume | 13 |
Issue number | 3 |
DOIs | |
Publication status | Published - Jun 2017 |
Funding
This study was in part supported by the Dutch Government ZonMW (MKMD project number 40-42600-98-010) and by a EuroStars project (8855).
Funders | Funder number |
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Dutch Government ZonMW | 40-42600-98-010 |