Prospective Associations of Diet Quality With Incident Frailty in Older Adults: The Health, Aging, and Body Composition Study

Linda M Hengeveld, Hanneke A H Wijnhoven, Margreet R Olthof, Ingeborg A Brouwer, Eleanor M Simonsick, Stephen B Kritchevsky, Denise K Houston, Anne B Newman, Marjolein Visser

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

OBJECTIVE: To examine associations of diet quality indicators with 4-year incidence of frailty in community-dwelling older adults.

DESIGN: Prospective cohort study.

SETTING: Health, Aging, and Body Composition Study, United States.

PARTICIPANTS: Community-dwelling men and women, aged 70 to 81 years in 1998 to 1999 (first follow-up, present study's baseline; n = 2154).

MEASUREMENTS: At first follow-up, dietary intake over the preceding year was assessed with a food frequency questionnaire. Indicators of diet quality include the Healthy Eating Index (categorized as poor, medium, and good), energy intake, and protein intake (a priori adjusted for energy intake using the nutrient residual model). Frailty status was determined using Fried's five-component frailty phenotype and categorized into "robust" (0 components present), "pre-frailty" (1 - 2 components present), or "frail" (3-5 components present). Cox proportional hazards analysis was used to examine associations of the diet quality indicators with 4-year incidence of (1) frailty and (2) pre-frailty or frailty. Competing risk analysis was used to examine associations with frailty by accounting for competing risks of death.

RESULTS: During the 4-year follow-up, 277 of the 2154 participants, robust or pre-frail at baseline, developed frailty, and 629 of the 1020 participants, robust at baseline, developed pre-frailty or frailty. Among the robust and pre-frail, after adjustment for confounders including energy intake, those consuming poor- and medium-quality diets had a higher frailty incidence than those consuming good-quality diets (hazard ratio [HR] = 1.92 [95% confidence interval {CI} = 1.17-3.17] and HR = 1.40 [95% CI = 0.99-1.98], respectively). No associations for energy or protein intake were observed. Competing risk analyses yielded similar results. Among the robust, those with lower vegetable protein intake had a higher "pre-frailty or frailty" incidence (per -10 g/d: HR = 1.20; 95% CI = 1.04-1.39). No other associations were observed.

CONCLUSION: Poorer overall diet quality and lower vegetable protein intake may increase the risk of becoming frail in old age. We found no association for intakes of energy, total protein, or animal protein.

Original languageEnglish
JournalJournal of the American Geriatrics Society
DOIs
Publication statusE-pub ahead of print - 2 Jul 2019

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Body Composition
Diet
Energy Intake
Health
Vegetable Proteins
Independent Living
Incidence
Confidence Intervals
Proteins
Food
Cohort Studies
Prospective Studies
Phenotype

Bibliographical note

© 2019 The Authors Journal of the American Geriatrics Society published by Wiley Periodicals, Inc. on behalf of The American Geriatrics Society.

Cite this

@article{e2b1570e7d4447478c9cde5a2f24e14f,
title = "Prospective Associations of Diet Quality With Incident Frailty in Older Adults: The Health, Aging, and Body Composition Study",
abstract = "OBJECTIVE: To examine associations of diet quality indicators with 4-year incidence of frailty in community-dwelling older adults.DESIGN: Prospective cohort study.SETTING: Health, Aging, and Body Composition Study, United States.PARTICIPANTS: Community-dwelling men and women, aged 70 to 81 years in 1998 to 1999 (first follow-up, present study's baseline; n = 2154).MEASUREMENTS: At first follow-up, dietary intake over the preceding year was assessed with a food frequency questionnaire. Indicators of diet quality include the Healthy Eating Index (categorized as poor, medium, and good), energy intake, and protein intake (a priori adjusted for energy intake using the nutrient residual model). Frailty status was determined using Fried's five-component frailty phenotype and categorized into {"}robust{"} (0 components present), {"}pre-frailty{"} (1 - 2 components present), or {"}frail{"} (3-5 components present). Cox proportional hazards analysis was used to examine associations of the diet quality indicators with 4-year incidence of (1) frailty and (2) pre-frailty or frailty. Competing risk analysis was used to examine associations with frailty by accounting for competing risks of death.RESULTS: During the 4-year follow-up, 277 of the 2154 participants, robust or pre-frail at baseline, developed frailty, and 629 of the 1020 participants, robust at baseline, developed pre-frailty or frailty. Among the robust and pre-frail, after adjustment for confounders including energy intake, those consuming poor- and medium-quality diets had a higher frailty incidence than those consuming good-quality diets (hazard ratio [HR] = 1.92 [95{\%} confidence interval {CI} = 1.17-3.17] and HR = 1.40 [95{\%} CI = 0.99-1.98], respectively). No associations for energy or protein intake were observed. Competing risk analyses yielded similar results. Among the robust, those with lower vegetable protein intake had a higher {"}pre-frailty or frailty{"} incidence (per -10 g/d: HR = 1.20; 95{\%} CI = 1.04-1.39). No other associations were observed.CONCLUSION: Poorer overall diet quality and lower vegetable protein intake may increase the risk of becoming frail in old age. We found no association for intakes of energy, total protein, or animal protein.",
author = "Hengeveld, {Linda M} and Wijnhoven, {Hanneke A H} and Olthof, {Margreet R} and Brouwer, {Ingeborg A} and Simonsick, {Eleanor M} and Kritchevsky, {Stephen B} and Houston, {Denise K} and Newman, {Anne B} and Marjolein Visser",
note = "{\circledC} 2019 The Authors Journal of the American Geriatrics Society published by Wiley Periodicals, Inc. on behalf of The American Geriatrics Society.",
year = "2019",
month = "7",
day = "2",
doi = "10.1111/jgs.16011",
language = "English",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",

}

Prospective Associations of Diet Quality With Incident Frailty in Older Adults : The Health, Aging, and Body Composition Study. / Hengeveld, Linda M; Wijnhoven, Hanneke A H; Olthof, Margreet R; Brouwer, Ingeborg A; Simonsick, Eleanor M; Kritchevsky, Stephen B; Houston, Denise K; Newman, Anne B; Visser, Marjolein.

In: Journal of the American Geriatrics Society, 02.07.2019.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Prospective Associations of Diet Quality With Incident Frailty in Older Adults

T2 - The Health, Aging, and Body Composition Study

AU - Hengeveld, Linda M

AU - Wijnhoven, Hanneke A H

AU - Olthof, Margreet R

AU - Brouwer, Ingeborg A

AU - Simonsick, Eleanor M

AU - Kritchevsky, Stephen B

AU - Houston, Denise K

AU - Newman, Anne B

AU - Visser, Marjolein

N1 - © 2019 The Authors Journal of the American Geriatrics Society published by Wiley Periodicals, Inc. on behalf of The American Geriatrics Society.

PY - 2019/7/2

Y1 - 2019/7/2

N2 - OBJECTIVE: To examine associations of diet quality indicators with 4-year incidence of frailty in community-dwelling older adults.DESIGN: Prospective cohort study.SETTING: Health, Aging, and Body Composition Study, United States.PARTICIPANTS: Community-dwelling men and women, aged 70 to 81 years in 1998 to 1999 (first follow-up, present study's baseline; n = 2154).MEASUREMENTS: At first follow-up, dietary intake over the preceding year was assessed with a food frequency questionnaire. Indicators of diet quality include the Healthy Eating Index (categorized as poor, medium, and good), energy intake, and protein intake (a priori adjusted for energy intake using the nutrient residual model). Frailty status was determined using Fried's five-component frailty phenotype and categorized into "robust" (0 components present), "pre-frailty" (1 - 2 components present), or "frail" (3-5 components present). Cox proportional hazards analysis was used to examine associations of the diet quality indicators with 4-year incidence of (1) frailty and (2) pre-frailty or frailty. Competing risk analysis was used to examine associations with frailty by accounting for competing risks of death.RESULTS: During the 4-year follow-up, 277 of the 2154 participants, robust or pre-frail at baseline, developed frailty, and 629 of the 1020 participants, robust at baseline, developed pre-frailty or frailty. Among the robust and pre-frail, after adjustment for confounders including energy intake, those consuming poor- and medium-quality diets had a higher frailty incidence than those consuming good-quality diets (hazard ratio [HR] = 1.92 [95% confidence interval {CI} = 1.17-3.17] and HR = 1.40 [95% CI = 0.99-1.98], respectively). No associations for energy or protein intake were observed. Competing risk analyses yielded similar results. Among the robust, those with lower vegetable protein intake had a higher "pre-frailty or frailty" incidence (per -10 g/d: HR = 1.20; 95% CI = 1.04-1.39). No other associations were observed.CONCLUSION: Poorer overall diet quality and lower vegetable protein intake may increase the risk of becoming frail in old age. We found no association for intakes of energy, total protein, or animal protein.

AB - OBJECTIVE: To examine associations of diet quality indicators with 4-year incidence of frailty in community-dwelling older adults.DESIGN: Prospective cohort study.SETTING: Health, Aging, and Body Composition Study, United States.PARTICIPANTS: Community-dwelling men and women, aged 70 to 81 years in 1998 to 1999 (first follow-up, present study's baseline; n = 2154).MEASUREMENTS: At first follow-up, dietary intake over the preceding year was assessed with a food frequency questionnaire. Indicators of diet quality include the Healthy Eating Index (categorized as poor, medium, and good), energy intake, and protein intake (a priori adjusted for energy intake using the nutrient residual model). Frailty status was determined using Fried's five-component frailty phenotype and categorized into "robust" (0 components present), "pre-frailty" (1 - 2 components present), or "frail" (3-5 components present). Cox proportional hazards analysis was used to examine associations of the diet quality indicators with 4-year incidence of (1) frailty and (2) pre-frailty or frailty. Competing risk analysis was used to examine associations with frailty by accounting for competing risks of death.RESULTS: During the 4-year follow-up, 277 of the 2154 participants, robust or pre-frail at baseline, developed frailty, and 629 of the 1020 participants, robust at baseline, developed pre-frailty or frailty. Among the robust and pre-frail, after adjustment for confounders including energy intake, those consuming poor- and medium-quality diets had a higher frailty incidence than those consuming good-quality diets (hazard ratio [HR] = 1.92 [95% confidence interval {CI} = 1.17-3.17] and HR = 1.40 [95% CI = 0.99-1.98], respectively). No associations for energy or protein intake were observed. Competing risk analyses yielded similar results. Among the robust, those with lower vegetable protein intake had a higher "pre-frailty or frailty" incidence (per -10 g/d: HR = 1.20; 95% CI = 1.04-1.39). No other associations were observed.CONCLUSION: Poorer overall diet quality and lower vegetable protein intake may increase the risk of becoming frail in old age. We found no association for intakes of energy, total protein, or animal protein.

U2 - 10.1111/jgs.16011

DO - 10.1111/jgs.16011

M3 - Article

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

ER -