TY - JOUR
T1 - Proteomic analysis of Taenia solium metacestode excretion-secretion proteins.
AU - Victor, B.
AU - Kanobana, K.
AU - Gabriel, S.
AU - Polman, K.
AU - Deckers, N.
AU - Dorny, P.
AU - Deelder, A.M.
AU - Palmblad, M.
PY - 2012
Y1 - 2012
N2 - The metacestode larval stage of Taenia solium is the causal agent of a zoonotic disease called cysticercosis. The disease has an important impact on pork trade (due to porcine cysticercosis) and public health (due to human neurocysticercosis). In order to improve the current diagnostic tools and to get a better understanding of the interaction between T. solium metacestodes and their host, there is a need for more information about the proteins that are released by the parasite. In this study, we used protein sequences from different helminths, 1DE, reversed-phase LC, and MS/MS to analyze the excretion-secretion proteins produced by T. solium metacestodes from infected pigs. This is the first report of the T. solium metacestode excretion-secretion proteome. We report 76 proteins including 27 already described T. solium proteins, 17 host proteins and 32 proteins likely to be of T. solium origin, but identified using sequences from other helminths. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
AB - The metacestode larval stage of Taenia solium is the causal agent of a zoonotic disease called cysticercosis. The disease has an important impact on pork trade (due to porcine cysticercosis) and public health (due to human neurocysticercosis). In order to improve the current diagnostic tools and to get a better understanding of the interaction between T. solium metacestodes and their host, there is a need for more information about the proteins that are released by the parasite. In this study, we used protein sequences from different helminths, 1DE, reversed-phase LC, and MS/MS to analyze the excretion-secretion proteins produced by T. solium metacestodes from infected pigs. This is the first report of the T. solium metacestode excretion-secretion proteome. We report 76 proteins including 27 already described T. solium proteins, 17 host proteins and 32 proteins likely to be of T. solium origin, but identified using sequences from other helminths. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
U2 - 10.1002/pmic.201100496
DO - 10.1002/pmic.201100496
M3 - Article
SN - 1874-3919
VL - 12
SP - 1860
EP - 1869
JO - Journal of Proteomics
JF - Journal of Proteomics
IS - 11
ER -