Psycho-educational interventions focused on maternal or infant sleep for pregnant women to prevent the onset of antenatal and postnatal depression: A systematic review

Natsu Sasaki, Naonori Yasuma, Erika Obikane, Zui Narita, Junpei Sekiya, Takuma Inagawa, Aiichiro Nakajima, Yuji Yamada, Ryuichi Yamazaki, Asami Matsunaga, Tomomi Saito, Kotaro Imamura, Kazuhiro Watanabe, Norito Kawakami, Daisuke Nishi*

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review


Aims: This systematic review aimed to evaluate randomized controlled trials (RCTs) to examine the effect of maternal and infant sleep intervention during women's pregnancy for the purpose of preventing perinatal depression. Method: A systematic search (from inception to January 28, 2019) for RCTs using five electronic databases—the Cochrane Controlled Register of Trials (CENTRAL), Embase, PubMed, PsycINFO, and Ichushi Web (Japan Medical Abstracts Society)—was conducted. Twelve investigators independently conducted initial screenings based on title and abstract, and then, two researchers performed full-text reviews one by one. A meta-analysis would be conducted if at least three studies were found. However, only two articles that met inclusion criteria, and narrative data synthesis was conducted for these two articles. The study protocol has been registered at PROSPERO (CRD42019119999). Result: A total of 13 654 studies were initially searched. After removing duplicates, 10 547 studies were screened, and finally, two studies met the inclusion criteria. In both studies, the intervention was a one-time face-to-face session during pregnancy to deliver the behavioral knowledge and skills for optimizing sleep hygiene for both infant and mother. Effectiveness of the intervention in improving maternal mood was not significant in one study. In the other, there was a significant difference in maternal mood between the intervention and control group. No mood comparison was made between baseline and postintervention. Conclusion: This study found limited evidence to support the effectiveness of sleep intervention for all pregnant women, which means “universal intervention,” to protect maternal mental health. Further well-designed RCTs are needed to confirm these findings.

Original languageEnglish
Pages (from-to)2-13
Number of pages12
JournalNeuropsychopharmacology Reports
Issue number1
Early online date19 Dec 2020
Publication statusPublished - Mar 2021

Bibliographical note

Funding Information:
This work was supported by the Japan Society for the Promotion of Science under a Grant‐in‐Aid for Scientific Research (A) (19H01073 to DN) The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Publisher Copyright:
© 2020 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Society of NeuropsychoPharmacology.

Copyright 2021 Elsevier B.V., All rights reserved.


  • antenatal depression
  • CBT-I
  • maternal and child health (MCH)
  • postnatal depression
  • sleep disturbance
  • sleep hygiene
  • universal prevention


Dive into the research topics of 'Psycho-educational interventions focused on maternal or infant sleep for pregnant women to prevent the onset of antenatal and postnatal depression: A systematic review'. Together they form a unique fingerprint.

Cite this