TY - JOUR
T1 - PTH: A New Target in Arteriosclerosis?
AU - Buizert, P.J.
AU - van Schoor, N.M.
AU - Simsek, S.
AU - Lips, P.T.A.M.
AU - Heijboer, A.C.
AU - den Heijer, M.
AU - Deeg, D.J.H.
AU - Eekhoff, E.M.W.
PY - 2013
Y1 - 2013
N2 - Context: Growing evidence demonstrates that hyperparathyroidism is associated with an increased risk of cardiovascular morbidity and mortality. However, little is known about the relation between serum PTH levels within the normal range and cardiovascular diseases (CVD). Objective: In this study the relationship of serum PTH levels within the normal range with CVD and abdominal aortic calcifications was investigated. Design: A cross-sectional, population-based study was performed using data of the Longitudinal Aging Study Amsterdam, including 558 men and 537 women, aged 65-88 years. Models were controlled for sex, age, body mass index, hypertension, diabetes mellitus, high-density lipoprotein cholesterol, total cholesterol, smoking, physical activity, alcohol consumption, glomerular filtration rate, season of blood collection, calcium or diuretic use, and serum 25-hydroxyvitamin D and osteocalcin levels when these variables were found to be relevant confounders. Results: Multivariate models showed that subjects in the highest quintile of serum PTH had a significantly higher risk of CVD as compared with subjects in the lowest quintile (odds ratio 2.22, confidence interval 1.39-3.56). The relationship between PTH and abdominal aortic calcifications was observed only in men, which remained significant after adjusting for confounders (odds ratio 4.03, confidence interval 1.50-10.83). Conclusions: This study demonstrated that in older persons the presence of serum PTH levels within the upper normal range is highly related to CVD. In men, this association may partly be explained by calcifications of the abdominal aorta. Because CVD poses an important health risk, further elucidation of the role of serum PTH inCVDand arteriosclerosis is relevant. (J Clin Endocrinol Metab 98: E1583-E1590, 2013). Copyright © 2013 by The Endocrine Society.
AB - Context: Growing evidence demonstrates that hyperparathyroidism is associated with an increased risk of cardiovascular morbidity and mortality. However, little is known about the relation between serum PTH levels within the normal range and cardiovascular diseases (CVD). Objective: In this study the relationship of serum PTH levels within the normal range with CVD and abdominal aortic calcifications was investigated. Design: A cross-sectional, population-based study was performed using data of the Longitudinal Aging Study Amsterdam, including 558 men and 537 women, aged 65-88 years. Models were controlled for sex, age, body mass index, hypertension, diabetes mellitus, high-density lipoprotein cholesterol, total cholesterol, smoking, physical activity, alcohol consumption, glomerular filtration rate, season of blood collection, calcium or diuretic use, and serum 25-hydroxyvitamin D and osteocalcin levels when these variables were found to be relevant confounders. Results: Multivariate models showed that subjects in the highest quintile of serum PTH had a significantly higher risk of CVD as compared with subjects in the lowest quintile (odds ratio 2.22, confidence interval 1.39-3.56). The relationship between PTH and abdominal aortic calcifications was observed only in men, which remained significant after adjusting for confounders (odds ratio 4.03, confidence interval 1.50-10.83). Conclusions: This study demonstrated that in older persons the presence of serum PTH levels within the upper normal range is highly related to CVD. In men, this association may partly be explained by calcifications of the abdominal aorta. Because CVD poses an important health risk, further elucidation of the role of serum PTH inCVDand arteriosclerosis is relevant. (J Clin Endocrinol Metab 98: E1583-E1590, 2013). Copyright © 2013 by The Endocrine Society.
U2 - 10.1210/jc.2013-1621
DO - 10.1210/jc.2013-1621
M3 - Article
VL - 98
SP - E1583-E1590
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 10
ER -