TY - JOUR
T1 - Public-private partnerships influencing the initiation and duration of clinical trials for neglected tropical diseases
AU - Ma, Zhongxuan
AU - Augustijn, Kevin
AU - De Esch, Iwan
AU - Bossink, Bart
N1 - Publisher Copyright:
© 2023 Ma et al.
PY - 2023/11
Y1 - 2023/11
N2 - Public-private partnerships (PPPs) for neglected tropical diseases (NTDs) are often studied as an organizational form that facilitates the management and control of the huge costs of drug research and development. Especially the later stages of drug development, including clinical trials, become very expensive. This present study investigates whether and how the type of PPPs influences the initiation and duration of NTD clinical trials. Using the Clinical-Trials.gov database, a dataset of 1175 NTD clinical studies that started between 2000 and 2021 is analyzed based on affiliation information and project duration. For the NTD clinical trials that resulted from PPPs, the collaborating types were determined and analyzed, including the public sector-, private sector-, governmental sector-, and nongovernmental organization-led collaborations. The determinants for the discontinuation of all stopped clinical trials were categorized into scientific-, funding-, political-, and logistic dimensions. The results reveal that public sector-led PPPs were the most common collaborative types, and logistic and scientific issues were the most frequent determinants of stopped clinical trials. Trial registration: ClinicalTrials.gov.
AB - Public-private partnerships (PPPs) for neglected tropical diseases (NTDs) are often studied as an organizational form that facilitates the management and control of the huge costs of drug research and development. Especially the later stages of drug development, including clinical trials, become very expensive. This present study investigates whether and how the type of PPPs influences the initiation and duration of NTD clinical trials. Using the Clinical-Trials.gov database, a dataset of 1175 NTD clinical studies that started between 2000 and 2021 is analyzed based on affiliation information and project duration. For the NTD clinical trials that resulted from PPPs, the collaborating types were determined and analyzed, including the public sector-, private sector-, governmental sector-, and nongovernmental organization-led collaborations. The determinants for the discontinuation of all stopped clinical trials were categorized into scientific-, funding-, political-, and logistic dimensions. The results reveal that public sector-led PPPs were the most common collaborative types, and logistic and scientific issues were the most frequent determinants of stopped clinical trials. Trial registration: ClinicalTrials.gov.
KW - Innovation, co-innovation
UR - http://www.scopus.com/inward/record.url?scp=85178464632&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85178464632&partnerID=8YFLogxK
U2 - 10.1371/journal.pntd.0011760
DO - 10.1371/journal.pntd.0011760
M3 - Article
C2 - 37956165
AN - SCOPUS:85178464632
SN - 1935-2735
VL - 17
SP - 1
EP - 14
JO - PLoS Neglected Tropical Diseases
JF - PLoS Neglected Tropical Diseases
IS - 11
M1 - e0011760
ER -