Pure non-dioxin-like PCB congeners suppress induction of the AhR-dependent endpoints in rat liver cells

J. Brenerová; T. Hamers; J.H. Kamstra; J. Vondráček; S. Strapáčová; P.L. Andersson; M. Machala

doi:10.1007/s11356-015-4819-6

Pure non-dioxin-like PCB congeners suppress induction of the AhR-dependent endpoints in rat liver cells

J. Brenerová, T. Hamers, J.H. Kamstra, J. Vondráček, S. Strapáčová, P.L. Andersson, M. Machala

Chemistry and Biology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The relative potencies of non-ortho-substituted coplanar polychlorinated biphenyl (PCB) congeners to activate the aryl hydrocarbon receptor (AhR) and to cause the AhR-dependent toxic events are essential for their risk assessment. Since some studies suggested that abundant non-dioxin-like PCB congeners (NDL-PCBs) may alter the AhR activation by PCB mixtures and possibly cause non-additive effects, we evaluated potential suppressive effects of NDL-PCBs on AhR activation, using a series of 24 highly purified NDL-PCBs. We investigated their impact on the model AhR agonist-induced luciferase reporter gene expression in rat hepatoma cells and on induction of CYP1A1/1B1 mRNAs and deregulation of AhR-dependent cell proliferation in rat liver epithelial cells. PCBs 128, 138, and 170 significantly suppressed AhR activation (with IC

Original language	English
Pages (from-to)	2099-2107
Journal	Environmental Science and Pollution Research International
Volume	23
Issue number	3
Early online date	17 Jun 2015
DOIs	https://doi.org/10.1007/s11356-015-4819-6
Publication status	Published - 2016

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@article{96d16f9a26904cbbb7578bbc2a05e4e6,

title = "Pure non-dioxin-like PCB congeners suppress induction of the AhR-dependent endpoints in rat liver cells",

abstract = "The relative potencies of non-ortho-substituted coplanar polychlorinated biphenyl (PCB) congeners to activate the aryl hydrocarbon receptor (AhR) and to cause the AhR-dependent toxic events are essential for their risk assessment. Since some studies suggested that abundant non-dioxin-like PCB congeners (NDL-PCBs) may alter the AhR activation by PCB mixtures and possibly cause non-additive effects, we evaluated potential suppressive effects of NDL-PCBs on AhR activation, using a series of 24 highly purified NDL-PCBs. We investigated their impact on the model AhR agonist-induced luciferase reporter gene expression in rat hepatoma cells and on induction of CYP1A1/1B1 mRNAs and deregulation of AhR-dependent cell proliferation in rat liver epithelial cells. PCBs 128, 138, and 170 significantly suppressed AhR activation (with IC",

author = "J. Brenerov{\'a} and T. Hamers and J.H. Kamstra and J. Vondr{\'a}{\v c}ek and S. Strap{\'a}{\v c}ov{\'a} and P.L. Andersson and M. Machala",

year = "2016",

doi = "10.1007/s11356-015-4819-6",

language = "English",

volume = "23",

pages = "2099--2107",

journal = "Environmental Science and Pollution Research International",

issn = "0944-1344",

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Pure non-dioxin-like PCB congeners suppress induction of the AhR-dependent endpoints in rat liver cells. / Brenerová, J.; Hamers, T.; Kamstra, J.H.; Vondráček, J.; Strapáčová, S.; Andersson, P.L.; Machala, M.

In: Environmental Science and Pollution Research International, Vol. 23, No. 3, 2016, p. 2099-2107.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Pure non-dioxin-like PCB congeners suppress induction of the AhR-dependent endpoints in rat liver cells

AU - Brenerová, J.

AU - Hamers, T.

AU - Kamstra, J.H.

AU - Vondráček, J.

AU - Strapáčová, S.

AU - Andersson, P.L.

AU - Machala, M.

PY - 2016

Y1 - 2016

N2 - The relative potencies of non-ortho-substituted coplanar polychlorinated biphenyl (PCB) congeners to activate the aryl hydrocarbon receptor (AhR) and to cause the AhR-dependent toxic events are essential for their risk assessment. Since some studies suggested that abundant non-dioxin-like PCB congeners (NDL-PCBs) may alter the AhR activation by PCB mixtures and possibly cause non-additive effects, we evaluated potential suppressive effects of NDL-PCBs on AhR activation, using a series of 24 highly purified NDL-PCBs. We investigated their impact on the model AhR agonist-induced luciferase reporter gene expression in rat hepatoma cells and on induction of CYP1A1/1B1 mRNAs and deregulation of AhR-dependent cell proliferation in rat liver epithelial cells. PCBs 128, 138, and 170 significantly suppressed AhR activation (with IC

AB - The relative potencies of non-ortho-substituted coplanar polychlorinated biphenyl (PCB) congeners to activate the aryl hydrocarbon receptor (AhR) and to cause the AhR-dependent toxic events are essential for their risk assessment. Since some studies suggested that abundant non-dioxin-like PCB congeners (NDL-PCBs) may alter the AhR activation by PCB mixtures and possibly cause non-additive effects, we evaluated potential suppressive effects of NDL-PCBs on AhR activation, using a series of 24 highly purified NDL-PCBs. We investigated their impact on the model AhR agonist-induced luciferase reporter gene expression in rat hepatoma cells and on induction of CYP1A1/1B1 mRNAs and deregulation of AhR-dependent cell proliferation in rat liver epithelial cells. PCBs 128, 138, and 170 significantly suppressed AhR activation (with IC

U2 - 10.1007/s11356-015-4819-6

DO - 10.1007/s11356-015-4819-6

M3 - Article

VL - 23

SP - 2099

EP - 2107

JO - Environmental Science and Pollution Research International

JF - Environmental Science and Pollution Research International

SN - 0944-1344

IS - 3

ER -