Pure non-dioxin-like PCB congeners suppress induction of the AhR-dependent endpoints in rat liver cells

J. Brenerová, T. Hamers, J.H. Kamstra, J. Vondráček, S. Strapáčová, P.L. Andersson, M. Machala

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The relative potencies of non-ortho-substituted coplanar polychlorinated biphenyl (PCB) congeners to activate the aryl hydrocarbon receptor (AhR) and to cause the AhR-dependent toxic events are essential for their risk assessment. Since some studies suggested that abundant non-dioxin-like PCB congeners (NDL-PCBs) may alter the AhR activation by PCB mixtures and possibly cause non-additive effects, we evaluated potential suppressive effects of NDL-PCBs on AhR activation, using a series of 24 highly purified NDL-PCBs. We investigated their impact on the model AhR agonist-induced luciferase reporter gene expression in rat hepatoma cells and on induction of CYP1A1/1B1 mRNAs and deregulation of AhR-dependent cell proliferation in rat liver epithelial cells. PCBs 128, 138, and 170 significantly suppressed AhR activation (with IC
Original languageEnglish
Pages (from-to)2099-2107
JournalEnvironmental Science and Pollution Research International
Volume23
Issue number3
Early online date17 Jun 2015
DOIs
Publication statusPublished - 2016

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