TY - JOUR
T1 - Pure non-dioxin-like PCB congeners suppress induction of the AhR-dependent endpoints in rat liver cells
AU - Brenerová, J.
AU - Hamers, T.
AU - Kamstra, J.H.
AU - Vondráček, J.
AU - Strapáčová, S.
AU - Andersson, P.L.
AU - Machala, M.
PY - 2016
Y1 - 2016
N2 - The relative potencies of non-ortho-substituted coplanar polychlorinated biphenyl (PCB) congeners to activate the aryl hydrocarbon receptor (AhR) and to cause the AhR-dependent toxic events are essential for their risk assessment. Since some studies suggested that abundant non-dioxin-like PCB congeners (NDL-PCBs) may alter the AhR activation by PCB mixtures and possibly cause non-additive effects, we evaluated potential suppressive effects of NDL-PCBs on AhR activation, using a series of 24 highly purified NDL-PCBs. We investigated their impact on the model AhR agonist-induced luciferase reporter gene expression in rat hepatoma cells and on induction of CYP1A1/1B1 mRNAs and deregulation of AhR-dependent cell proliferation in rat liver epithelial cells. PCBs 128, 138, and 170 significantly suppressed AhR activation (with IC
AB - The relative potencies of non-ortho-substituted coplanar polychlorinated biphenyl (PCB) congeners to activate the aryl hydrocarbon receptor (AhR) and to cause the AhR-dependent toxic events are essential for their risk assessment. Since some studies suggested that abundant non-dioxin-like PCB congeners (NDL-PCBs) may alter the AhR activation by PCB mixtures and possibly cause non-additive effects, we evaluated potential suppressive effects of NDL-PCBs on AhR activation, using a series of 24 highly purified NDL-PCBs. We investigated their impact on the model AhR agonist-induced luciferase reporter gene expression in rat hepatoma cells and on induction of CYP1A1/1B1 mRNAs and deregulation of AhR-dependent cell proliferation in rat liver epithelial cells. PCBs 128, 138, and 170 significantly suppressed AhR activation (with IC
U2 - 10.1007/s11356-015-4819-6
DO - 10.1007/s11356-015-4819-6
M3 - Article
SN - 0944-1344
VL - 23
SP - 2099
EP - 2107
JO - Environmental Science and Pollution Research International
JF - Environmental Science and Pollution Research International
IS - 3
ER -
