TY - JOUR
T1 - Purkinje Cells Directly Inhibit Granule Cells in Specialized Regions of the Cerebellar Cortex
AU - Guo, Chong
AU - Witter, Laurens
AU - Rudolph, Stephanie
AU - Elliott, Hunter L.
AU - Ennis, Katelin A.
AU - Regehr, Wade G.
PY - 2016/9/21
Y1 - 2016/9/21
N2 - Inhibition of granule cells plays a key role in gating the flow of signals into the cerebellum, and it is thought that Golgi cells are the only interneurons that inhibit granule cells. Here we show that Purkinje cells, the sole output neurons of the cerebellar cortex, also directly inhibit granule cells via their axon collaterals. Anatomical and optogenetic studies indicate that this non-canonical feedback is region specific: it is most prominent in lobules that regulate eye movement and process vestibular information. Collaterals provide fast, slow, and tonic inhibition to granule cells, and thus allow Purkinje cells to regulate granule cell excitability on multiple timescales. We propose that this feedback mechanism could regulate excitability of the input layer, contribute to sparse coding, and mediate temporal integration.
AB - Inhibition of granule cells plays a key role in gating the flow of signals into the cerebellum, and it is thought that Golgi cells are the only interneurons that inhibit granule cells. Here we show that Purkinje cells, the sole output neurons of the cerebellar cortex, also directly inhibit granule cells via their axon collaterals. Anatomical and optogenetic studies indicate that this non-canonical feedback is region specific: it is most prominent in lobules that regulate eye movement and process vestibular information. Collaterals provide fast, slow, and tonic inhibition to granule cells, and thus allow Purkinje cells to regulate granule cell excitability on multiple timescales. We propose that this feedback mechanism could regulate excitability of the input layer, contribute to sparse coding, and mediate temporal integration.
UR - http://www.scopus.com/inward/record.url?scp=84991246111&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84991246111&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2016.08.011
DO - 10.1016/j.neuron.2016.08.011
M3 - Article
C2 - 27593180
AN - SCOPUS:84991246111
SN - 0896-6273
VL - 91
SP - 1330
EP - 1341
JO - Neuron
JF - Neuron
IS - 6
ER -