Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity and cellular ATP levels.

P. Lu, A.C. Haagsma, H. Pham, J.J. Maaskant, S. Mol, H. Lill, D. Bald

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Abstract

Pyrazinoic acid, the active form of the first-line antituberculosis drug pyrazinamide, decreased the proton motive force and respiratory ATP synthesis rates in subcellular mycobacterial membrane assays. Pyrazinoic acid also significantly lowered cellular ATP levels in Mycobacterium bovis BCG. These results indicate that the predominant mechanism of killing by this drug may operate by depletion of cellular ATP reserves. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Original languageEnglish
Pages (from-to)5354-5357
JournalAntimicrobial Agents and Chemotherapy
Volume55
Issue number11
DOIs
Publication statusPublished - 2011

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