Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity and cellular ATP levels.

P. Lu; A.C. Haagsma; H. Pham; J.J. Maaskant; S. Mol; H. Lill; D. Bald

doi:10.1128/AAC.00507-11

Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity and cellular ATP levels.

P. Lu, A.C. Haagsma, H. Pham, J.J. Maaskant, S. Mol, H. Lill, D. Bald

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Abstract

Pyrazinoic acid, the active form of the first-line antituberculosis drug pyrazinamide, decreased the proton motive force and respiratory ATP synthesis rates in subcellular mycobacterial membrane assays. Pyrazinoic acid also significantly lowered cellular ATP levels in Mycobacterium bovis BCG. These results indicate that the predominant mechanism of killing by this drug may operate by depletion of cellular ATP reserves. Copyright © 2011, American Society for Microbiology. All Rights Reserved.

Original language	English
Pages (from-to)	5354-5357
Journal	Antimicrobial Agents and Chemotherapy
Volume	55
Issue number	11
DOIs	https://doi.org/10.1128/AAC.00507-11
Publication status	Published - 2011

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title = "Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity and cellular ATP levels.",

abstract = "Pyrazinoic acid, the active form of the first-line antituberculosis drug pyrazinamide, decreased the proton motive force and respiratory ATP synthesis rates in subcellular mycobacterial membrane assays. Pyrazinoic acid also significantly lowered cellular ATP levels in Mycobacterium bovis BCG. These results indicate that the predominant mechanism of killing by this drug may operate by depletion of cellular ATP reserves. Copyright {\textcopyright} 2011, American Society for Microbiology. All Rights Reserved.",

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AU - Lu, P.

AU - Haagsma, A.C.

AU - Pham, H.

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AU - Mol, S.

AU - Lill, H.

AU - Bald, D.

PY - 2011

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N2 - Pyrazinoic acid, the active form of the first-line antituberculosis drug pyrazinamide, decreased the proton motive force and respiratory ATP synthesis rates in subcellular mycobacterial membrane assays. Pyrazinoic acid also significantly lowered cellular ATP levels in Mycobacterium bovis BCG. These results indicate that the predominant mechanism of killing by this drug may operate by depletion of cellular ATP reserves. Copyright © 2011, American Society for Microbiology. All Rights Reserved.

AB - Pyrazinoic acid, the active form of the first-line antituberculosis drug pyrazinamide, decreased the proton motive force and respiratory ATP synthesis rates in subcellular mycobacterial membrane assays. Pyrazinoic acid also significantly lowered cellular ATP levels in Mycobacterium bovis BCG. These results indicate that the predominant mechanism of killing by this drug may operate by depletion of cellular ATP reserves. Copyright © 2011, American Society for Microbiology. All Rights Reserved.

U2 - 10.1128/AAC.00507-11

DO - 10.1128/AAC.00507-11

M3 - Article

SN - 0066-4804

VL - 55

SP - 5354

EP - 5357

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -

Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity and cellular ATP levels.

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