QDR 4500A DXA overestimates fat-free mass compared with criterion methods

Frances A Tylavsky; Timothy Lohman; Barbara A Blunt; Dale A Schoeller; Thomas Fuerst; Jane A Cauley; Michael C Nevitt; Marjolein Visser; Tamara B Harris

doi:10.1152/japplphysiol.00732.2002

QDR 4500A DXA overestimates fat-free mass compared with criterion methods

Frances A Tylavsky, Timothy Lohman, Barbara A Blunt, Dale A Schoeller, Thomas Fuerst, Jane A Cauley, Michael C Nevitt, Marjolein Visser, Tamara B Harris

Nutrition and Health

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

This study evaluated the accuracy with which the dual-energy X-ray absorptiometer (Hologic QDR 4500A) measured fat-free mass (FFM), fat mass (FM), and hydration of FFM. In a study of 58 men and women (ages 70-79 yr), the QDR 4500A was found to provide a systematically higher estimate of FFM and lower estimate of FM than a four-component model of body composition. A correction factor from this study was developed and applied to two other samples (n = 13 and 37). We found mean corrected levels of FFM and FM to be equivalent to that obtained by the four-component model or total body water. In addition, the hydration of the corrected FFM was closer to the established hydration level in adult samples and that obtained from the four-component model. These findings suggest that the current calibration of the fan-beam system of the Hologic QDR 4500A provides an overestimate of FFM and underestimate of FM compared with reference methods.

Original language	English
Pages (from-to)	959-65
Number of pages	7
Journal	Journal of Applied Physiology (1985)
Volume	94
Issue number	3
DOIs	https://doi.org/10.1152/japplphysiol.00732.2002
Publication status	Published - Mar 2003

Keywords

Absorptiometry, Photon
Aged
Aging
Algorithms
Body Composition
Body Mass Index
Calibration
Female
Humans
Male
Models, Biological
Reference Values
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1152/japplphysiol.00732.2002

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title = "QDR 4500A DXA overestimates fat-free mass compared with criterion methods",

abstract = "This study evaluated the accuracy with which the dual-energy X-ray absorptiometer (Hologic QDR 4500A) measured fat-free mass (FFM), fat mass (FM), and hydration of FFM. In a study of 58 men and women (ages 70-79 yr), the QDR 4500A was found to provide a systematically higher estimate of FFM and lower estimate of FM than a four-component model of body composition. A correction factor from this study was developed and applied to two other samples (n = 13 and 37). We found mean corrected levels of FFM and FM to be equivalent to that obtained by the four-component model or total body water. In addition, the hydration of the corrected FFM was closer to the established hydration level in adult samples and that obtained from the four-component model. These findings suggest that the current calibration of the fan-beam system of the Hologic QDR 4500A provides an overestimate of FFM and underestimate of FM compared with reference methods.",

keywords = "Absorptiometry, Photon, Aged, Aging, Algorithms, Body Composition, Body Mass Index, Calibration, Female, Humans, Male, Models, Biological, Reference Values, Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.",

author = "Tylavsky, {Frances A} and Timothy Lohman and Blunt, {Barbara A} and Schoeller, {Dale A} and Thomas Fuerst and Cauley, {Jane A} and Nevitt, {Michael C} and Marjolein Visser and Harris, {Tamara B}",

year = "2003",

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AU - Tylavsky, Frances A

AU - Lohman, Timothy

AU - Blunt, Barbara A

AU - Schoeller, Dale A

AU - Fuerst, Thomas

AU - Cauley, Jane A

AU - Nevitt, Michael C

AU - Visser, Marjolein

AU - Harris, Tamara B

PY - 2003/3

Y1 - 2003/3

N2 - This study evaluated the accuracy with which the dual-energy X-ray absorptiometer (Hologic QDR 4500A) measured fat-free mass (FFM), fat mass (FM), and hydration of FFM. In a study of 58 men and women (ages 70-79 yr), the QDR 4500A was found to provide a systematically higher estimate of FFM and lower estimate of FM than a four-component model of body composition. A correction factor from this study was developed and applied to two other samples (n = 13 and 37). We found mean corrected levels of FFM and FM to be equivalent to that obtained by the four-component model or total body water. In addition, the hydration of the corrected FFM was closer to the established hydration level in adult samples and that obtained from the four-component model. These findings suggest that the current calibration of the fan-beam system of the Hologic QDR 4500A provides an overestimate of FFM and underestimate of FM compared with reference methods.

AB - This study evaluated the accuracy with which the dual-energy X-ray absorptiometer (Hologic QDR 4500A) measured fat-free mass (FFM), fat mass (FM), and hydration of FFM. In a study of 58 men and women (ages 70-79 yr), the QDR 4500A was found to provide a systematically higher estimate of FFM and lower estimate of FM than a four-component model of body composition. A correction factor from this study was developed and applied to two other samples (n = 13 and 37). We found mean corrected levels of FFM and FM to be equivalent to that obtained by the four-component model or total body water. In addition, the hydration of the corrected FFM was closer to the established hydration level in adult samples and that obtained from the four-component model. These findings suggest that the current calibration of the fan-beam system of the Hologic QDR 4500A provides an overestimate of FFM and underestimate of FM compared with reference methods.

KW - Absorptiometry, Photon

KW - Aged

KW - Aging

KW - Algorithms

KW - Body Composition

KW - Body Mass Index

KW - Calibration

KW - Female

KW - Humans

KW - Male

KW - Models, Biological

KW - Reference Values

KW - Clinical Trial

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, P.H.S.

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JO - Journal of Applied Physiology (1985)

JF - Journal of Applied Physiology (1985)

IS - 3

ER -

QDR 4500A DXA overestimates fat-free mass compared with criterion methods

Abstract

Keywords

UN SDGs

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