qEEG Analysis in the Diagnosis of Alzheimer’s Disease: A Comparison of Functional Connectivity and Spectral Analysis

Alzheimer’s disease (AD) is a brain disorder that is mainly characterized by a progressive degeneration of neurons in the brain and decline of cognitive abilities. This study compared an FFT-based spectral analysis against a functional connectivity analysis for the diagnosis of AD. Both quantitative methods were applied on an EEG dataset including 20 diagnosed AD patients and 20 age-matched healthy controls (HC). The obtained results showed an advantage of the functional connectivity analysis when compared to the spectral analysis; while the latter could not find any significant differences between the AD and HC groups, the functional connectivity analysis showed statistically higher synchronization levels in the AD group in the lower frequency bands (delta and theta), suggesting a ‘phase-locked’ state in AD-affected brains. Further comparison of functional connectivity between the homotopic regions confirmed that the traits of AD were localized to the centro-parietal and centro-temporal areas in the theta frequency band (4–8 Hz). This study applies a neural metric for Alzheimer’s detection from a data science perspective rather than from a neuroscience one and shows that the combination of bipolar derivations with phase synchronization yields similar results to comparable studies employing alternative analysis methods.