Quality of Life Improves Following Laparoscopic Hemifundoplication in Neurologically Non-Impaired Children with Gastroesophageal Reflux Disease: A Propensity Score-Matched Analysis

Giovanni Frongia; Daniel Weitz; Jan Bauer; Pascal Probst; Franziska Steffens; Dennis Pfisterer; Arianeb Mehrabi; Patrick Günther

doi:10.1080/08941939.2020.1850943

Quality of Life Improves Following Laparoscopic Hemifundoplication in Neurologically Non-Impaired Children with Gastroesophageal Reflux Disease: A Propensity Score-Matched Analysis

Giovanni Frongia, Daniel Weitz, Jan Bauer, Pascal Probst, Franziska Steffens, Dennis Pfisterer, Arianeb Mehrabi, Patrick Günther

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

BACKGROUND: Quality of life (QOL) data following pediatric fundoplication for gastroesophageal reflux disease (GERD) are rare. Present study assessed the QOL in neurologically non-impaired children before and after laparoscopic hemifundoplication (LHF) in comparison to healthy controls.

METHODS: PedsQL™ questionnaires assessed data on gastrointestinal symptoms (GIS) and general well-being (GWB) were compared in a propensity score-matched analysis (60 patients' pairs for time-point of surgery and 51 for follow-up).

RESULTS: Preoperatively, the LHF group had more GIS (72.2 ± 53.9 vs. 38.8 ± 31.6; p < 0.001) and a lower GWB (16.7 ± 5.5 vs. 23.8 ± 3.5, p < 0.001) compared with controls. Postoperatively, GIS decreased significantly (74.3 ± 52.9 vs. 36.3 ± 33.5; p < 0.001) and the GWB was significantly higher (16.2 ± 6.0 vs. 20.8 ± 5.8; p < 0.001). GIS were similar in the LHF and control groups (39.1 ± 36.4 vs. 40.1 ± 31.0; p = 0.885) but GWB was lower in the LHF group than the control group (20.5 ± 6.3 vs. 23.4 ± 3.9; p = 0.009).

CONCLUSIONS: QOL significantly improves after LHF in neurologically non-impaired children.

Original language	English
Pages (from-to)	278-283
Number of pages	6
Journal	Journal of Investigative Surgery
Volume	35
Issue number	2
DOIs	https://doi.org/10.1080/08941939.2020.1850943
Publication status	Published - Feb 2022
Externally published	Yes

Keywords

Child
Fundoplication
Gastroesophageal Reflux/surgery
Humans
Laparoscopy
Propensity Score
Quality of Life
Treatment Outcome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/08941939.2020.1850943

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Frongia, G., Weitz, D., Bauer, J., Probst, P., Steffens, F., Pfisterer, D., Mehrabi, A., & Günther, P. (2022). Quality of Life Improves Following Laparoscopic Hemifundoplication in Neurologically Non-Impaired Children with Gastroesophageal Reflux Disease: A Propensity Score-Matched Analysis. Journal of Investigative Surgery, 35(2), 278-283. https://doi.org/10.1080/08941939.2020.1850943

@article{b71119a863f44030923585539c6552d7,

title = "Quality of Life Improves Following Laparoscopic Hemifundoplication in Neurologically Non-Impaired Children with Gastroesophageal Reflux Disease: A Propensity Score-Matched Analysis",

abstract = "BACKGROUND: Quality of life (QOL) data following pediatric fundoplication for gastroesophageal reflux disease (GERD) are rare. Present study assessed the QOL in neurologically non-impaired children before and after laparoscopic hemifundoplication (LHF) in comparison to healthy controls.METHODS: PedsQL{\texttrademark} questionnaires assessed data on gastrointestinal symptoms (GIS) and general well-being (GWB) were compared in a propensity score-matched analysis (60 patients' pairs for time-point of surgery and 51 for follow-up).RESULTS: Preoperatively, the LHF group had more GIS (72.2 ± 53.9 vs. 38.8 ± 31.6; p < 0.001) and a lower GWB (16.7 ± 5.5 vs. 23.8 ± 3.5, p < 0.001) compared with controls. Postoperatively, GIS decreased significantly (74.3 ± 52.9 vs. 36.3 ± 33.5; p < 0.001) and the GWB was significantly higher (16.2 ± 6.0 vs. 20.8 ± 5.8; p < 0.001). GIS were similar in the LHF and control groups (39.1 ± 36.4 vs. 40.1 ± 31.0; p = 0.885) but GWB was lower in the LHF group than the control group (20.5 ± 6.3 vs. 23.4 ± 3.9; p = 0.009).CONCLUSIONS: QOL significantly improves after LHF in neurologically non-impaired children.",

keywords = "Child, Fundoplication, Gastroesophageal Reflux/surgery, Humans, Laparoscopy, Propensity Score, Quality of Life, Treatment Outcome",

author = "Giovanni Frongia and Daniel Weitz and Jan Bauer and Pascal Probst and Franziska Steffens and Dennis Pfisterer and Arianeb Mehrabi and Patrick G{\"u}nther",

year = "2022",

month = feb,

doi = "10.1080/08941939.2020.1850943",

language = "English",

volume = "35",

pages = "278--283",

journal = "Journal of Investigative Surgery",

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publisher = "Informa Healthcare",

number = "2",

}

Frongia, G, Weitz, D, Bauer, J, Probst, P, Steffens, F, Pfisterer, D, Mehrabi, A & Günther, P 2022, 'Quality of Life Improves Following Laparoscopic Hemifundoplication in Neurologically Non-Impaired Children with Gastroesophageal Reflux Disease: A Propensity Score-Matched Analysis', Journal of Investigative Surgery, vol. 35, no. 2, pp. 278-283. https://doi.org/10.1080/08941939.2020.1850943

Quality of Life Improves Following Laparoscopic Hemifundoplication in Neurologically Non-Impaired Children with Gastroesophageal Reflux Disease: A Propensity Score-Matched Analysis. / Frongia, Giovanni; Weitz, Daniel; Bauer, Jan et al.
In: Journal of Investigative Surgery, Vol. 35, No. 2, 02.2022, p. 278-283.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Quality of Life Improves Following Laparoscopic Hemifundoplication in Neurologically Non-Impaired Children with Gastroesophageal Reflux Disease

T2 - A Propensity Score-Matched Analysis

AU - Frongia, Giovanni

AU - Weitz, Daniel

AU - Bauer, Jan

AU - Probst, Pascal

AU - Steffens, Franziska

AU - Pfisterer, Dennis

AU - Mehrabi, Arianeb

AU - Günther, Patrick

PY - 2022/2

Y1 - 2022/2

N2 - BACKGROUND: Quality of life (QOL) data following pediatric fundoplication for gastroesophageal reflux disease (GERD) are rare. Present study assessed the QOL in neurologically non-impaired children before and after laparoscopic hemifundoplication (LHF) in comparison to healthy controls.METHODS: PedsQL™ questionnaires assessed data on gastrointestinal symptoms (GIS) and general well-being (GWB) were compared in a propensity score-matched analysis (60 patients' pairs for time-point of surgery and 51 for follow-up).RESULTS: Preoperatively, the LHF group had more GIS (72.2 ± 53.9 vs. 38.8 ± 31.6; p < 0.001) and a lower GWB (16.7 ± 5.5 vs. 23.8 ± 3.5, p < 0.001) compared with controls. Postoperatively, GIS decreased significantly (74.3 ± 52.9 vs. 36.3 ± 33.5; p < 0.001) and the GWB was significantly higher (16.2 ± 6.0 vs. 20.8 ± 5.8; p < 0.001). GIS were similar in the LHF and control groups (39.1 ± 36.4 vs. 40.1 ± 31.0; p = 0.885) but GWB was lower in the LHF group than the control group (20.5 ± 6.3 vs. 23.4 ± 3.9; p = 0.009).CONCLUSIONS: QOL significantly improves after LHF in neurologically non-impaired children.

AB - BACKGROUND: Quality of life (QOL) data following pediatric fundoplication for gastroesophageal reflux disease (GERD) are rare. Present study assessed the QOL in neurologically non-impaired children before and after laparoscopic hemifundoplication (LHF) in comparison to healthy controls.METHODS: PedsQL™ questionnaires assessed data on gastrointestinal symptoms (GIS) and general well-being (GWB) were compared in a propensity score-matched analysis (60 patients' pairs for time-point of surgery and 51 for follow-up).RESULTS: Preoperatively, the LHF group had more GIS (72.2 ± 53.9 vs. 38.8 ± 31.6; p < 0.001) and a lower GWB (16.7 ± 5.5 vs. 23.8 ± 3.5, p < 0.001) compared with controls. Postoperatively, GIS decreased significantly (74.3 ± 52.9 vs. 36.3 ± 33.5; p < 0.001) and the GWB was significantly higher (16.2 ± 6.0 vs. 20.8 ± 5.8; p < 0.001). GIS were similar in the LHF and control groups (39.1 ± 36.4 vs. 40.1 ± 31.0; p = 0.885) but GWB was lower in the LHF group than the control group (20.5 ± 6.3 vs. 23.4 ± 3.9; p = 0.009).CONCLUSIONS: QOL significantly improves after LHF in neurologically non-impaired children.

KW - Child

KW - Fundoplication

KW - Gastroesophageal Reflux/surgery

KW - Humans

KW - Laparoscopy

KW - Propensity Score

KW - Quality of Life

KW - Treatment Outcome

U2 - 10.1080/08941939.2020.1850943

DO - 10.1080/08941939.2020.1850943

M3 - Article

C2 - 33251893

SN - 0894-1939

VL - 35

SP - 278

EP - 283

JO - Journal of Investigative Surgery

JF - Journal of Investigative Surgery

IS - 2

ER -

Quality of Life Improves Following Laparoscopic Hemifundoplication in Neurologically Non-Impaired Children with Gastroesophageal Reflux Disease: A Propensity Score-Matched Analysis

Abstract

Keywords

UN SDGs

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