(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

S. Syvanen, G. Luurtsema, C.F.M. Molthoff, A.D. Windhorst, M.C. Huisman, A.A. Lammertsma, R.A. Voskuyl, E.C.M. de Lange

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Background: Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy. In the rat, pharmacoresistant epilepsy can be mimicked by inducing status epilepticus by intraperitoneal injection of kainate, which leads to development of spontaneous seizures after 3 weeks to 3 months. The aim of this study was to investigate potential changes in P-glycoprotein (P-gp) expression and functionality at an early stage after induction of status epilepticus by kainate.Methods: (R)-[
    Original languageEnglish
    Article number1
    JournalBMC Medical Imaging
    Volume11
    DOIs
    Publication statusPublished - 2011

    Fingerprint

    Status Epilepticus
    Kainic Acid
    P-Glycoprotein
    Verapamil
    Blood-Brain Barrier
    Epilepsy
    Central Nervous System Diseases
    Intraperitoneal Injections
    Seizures
    Pharmaceutical Preparations

    Cite this

    Syvanen, S. ; Luurtsema, G. ; Molthoff, C.F.M. ; Windhorst, A.D. ; Huisman, M.C. ; Lammertsma, A.A. ; Voskuyl, R.A. ; de Lange, E.C.M. / (R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus. In: BMC Medical Imaging. 2011 ; Vol. 11.
    @article{6462581688b949aaa28d7e3b2d5e0444,
    title = "(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus",
    abstract = "Background: Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy. In the rat, pharmacoresistant epilepsy can be mimicked by inducing status epilepticus by intraperitoneal injection of kainate, which leads to development of spontaneous seizures after 3 weeks to 3 months. The aim of this study was to investigate potential changes in P-glycoprotein (P-gp) expression and functionality at an early stage after induction of status epilepticus by kainate.Methods: (R)-[",
    author = "S. Syvanen and G. Luurtsema and C.F.M. Molthoff and A.D. Windhorst and M.C. Huisman and A.A. Lammertsma and R.A. Voskuyl and {de Lange}, E.C.M.",
    year = "2011",
    doi = "10.1186/1471-2342-11-1",
    language = "English",
    volume = "11",
    journal = "BMC Medical Imaging",
    issn = "1471-2342",
    publisher = "BioMed Central",

    }

    (R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus. / Syvanen, S.; Luurtsema, G.; Molthoff, C.F.M.; Windhorst, A.D.; Huisman, M.C.; Lammertsma, A.A.; Voskuyl, R.A.; de Lange, E.C.M.

    In: BMC Medical Imaging, Vol. 11, 1, 2011.

    Research output: Contribution to JournalArticleAcademicpeer-review

    TY - JOUR

    T1 - (R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

    AU - Syvanen, S.

    AU - Luurtsema, G.

    AU - Molthoff, C.F.M.

    AU - Windhorst, A.D.

    AU - Huisman, M.C.

    AU - Lammertsma, A.A.

    AU - Voskuyl, R.A.

    AU - de Lange, E.C.M.

    PY - 2011

    Y1 - 2011

    N2 - Background: Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy. In the rat, pharmacoresistant epilepsy can be mimicked by inducing status epilepticus by intraperitoneal injection of kainate, which leads to development of spontaneous seizures after 3 weeks to 3 months. The aim of this study was to investigate potential changes in P-glycoprotein (P-gp) expression and functionality at an early stage after induction of status epilepticus by kainate.Methods: (R)-[

    AB - Background: Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy. In the rat, pharmacoresistant epilepsy can be mimicked by inducing status epilepticus by intraperitoneal injection of kainate, which leads to development of spontaneous seizures after 3 weeks to 3 months. The aim of this study was to investigate potential changes in P-glycoprotein (P-gp) expression and functionality at an early stage after induction of status epilepticus by kainate.Methods: (R)-[

    U2 - 10.1186/1471-2342-11-1

    DO - 10.1186/1471-2342-11-1

    M3 - Article

    VL - 11

    JO - BMC Medical Imaging

    JF - BMC Medical Imaging

    SN - 1471-2342

    M1 - 1

    ER -