(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

S. Syvanen; G. Luurtsema; C.F.M. Molthoff; A.D. Windhorst; M.C. Huisman; A.A. Lammertsma; R.A. Voskuyl; E.C.M. de Lange

doi:10.1186/1471-2342-11-1

(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

S. Syvanen
, G. Luurtsema
, C.F.M. Molthoff
, A.D. Windhorst
, M.C. Huisman
, A.A. Lammertsma
, R.A. Voskuyl
, E.C.M. de Lange

Research output: Contribution to Journal › Article › Academic › peer-review

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Abstract

Background: Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy. In the rat, pharmacoresistant epilepsy can be mimicked by inducing status epilepticus by intraperitoneal injection of kainate, which leads to development of spontaneous seizures after 3 weeks to 3 months. The aim of this study was to investigate potential changes in P-glycoprotein (P-gp) expression and functionality at an early stage after induction of status epilepticus by kainate.Methods: (R)-[

Original language	English
Article number	1
Journal	BMC Medical Imaging
Volume	11
DOIs	https://doi.org/10.1186/1471-2342-11-1
Publication status	Published - 2011

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Syvanen, S., Luurtsema, G., Molthoff, C. F. M., Windhorst, A. D., Huisman, M. C., Lammertsma, A. A., Voskuyl, R. A., & de Lange, E. C. M. (2011). (R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus. BMC Medical Imaging, 11, Article 1. https://doi.org/10.1186/1471-2342-11-1

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abstract = "Background: Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy. In the rat, pharmacoresistant epilepsy can be mimicked by inducing status epilepticus by intraperitoneal injection of kainate, which leads to development of spontaneous seizures after 3 weeks to 3 months. The aim of this study was to investigate potential changes in P-glycoprotein (P-gp) expression and functionality at an early stage after induction of status epilepticus by kainate.Methods: (R)-[",

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AU - Syvanen, S.

AU - Luurtsema, G.

AU - Molthoff, C.F.M.

AU - Windhorst, A.D.

AU - Huisman, M.C.

AU - Lammertsma, A.A.

AU - Voskuyl, R.A.

AU - de Lange, E.C.M.

PY - 2011

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M1 - 1

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(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

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