Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence

J. van Wijngaarden, R.A.M. Dhonukshe-Rutten, N.M. van Schoor, N. van der Velde, K.M. Swart, A. Enneman, S.C. van Dijk, E.M. Brouwer-Brolsma, M.C. Zillikens, J.B.J. van Meurs, J. Brug, A.G. Uitterlinden, P.T.A.M. Lips, L.C.P.G.M. de Groot

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    Abstract

    Background: Osteoporosis is a major health problem, and the economic burden is expected to rise due to an increase in life expectancy throughout the world. Current observational evidence suggests that an elevated homocysteine concentration and poor vitamin B
    Original languageEnglish
    Article number80
    JournalBMC Geriatrics
    Volume11
    DOIs
    Publication statusPublished - 2011

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