Real-time single-pixel camera ophthalmoscope

Benjamin Lochocki, Adrian Gambin-Regadera, Silvestre Manzanera, Esther Irles, Enrique Tajahuerce, Jesús Lancis, Pablo Artal

Research output: Contribution to JournalMeeting AbstractOther research output

Abstract

Purpose: The examination of the retina is crucial for early detection of any unwanted alteration. Although there are different successful implementations of retinal imaging devices (ophthalmoscopes), new robust systems able to operate under many eye’s conditions may have a practical importance. Here, we introduce, as a proof of concept, a novel approach to image the retina in real time using a single-pixel camera.
Methods: The Single-Pixel camera Ophthalmoscope (SPCO) is based on the concept of sequentially detecting the inner–product’s intensity of the object and a series of controlled base patterns. The image corresponding to the object is subsequently reconstructed computationally. The used configuration was a double-pass system that contains a digital micromirror device (DMD) creating a spatially coded illumination that were projected on the retina covering a field of around 16 degrees. The DMD was able to display series of Hadamard patterns with a rate up to 22 kHz. For each projected pattern, the reflected light coming from the retina is detected with an avalanche photomultiplier (single-point detector). After displaying a distinct number of patterns, an image of the retina is retrieved and displayed within our developed software interface in real-time. Results: Experimental results obtained using an artificial eye confirmed the viability of this approach. We were able to reconstruct images with a resolution up to 128 x 128 pixels. Furthermore, real-time video streaming with a frame-rate between 1 to 20 frames per second depending on the chosen resolution was produced. The use of sub-sampling techniques based in the spatial content of the images could either increase the frame rate or the image size. Since multiplexed illumination may offer a SNR improvement when compared to traditional approaches, this may reduce the light illuminating the eye. Conclusions: A novel approach to obtain images of the retina based in a single point detector has been proposed. The instrument (SPCO) operates in real-time and should be extremely tolerant to a variety of ocular conditions that typically degrade the images of the fundus, including large refractive errors or opacities. This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
Original languageEnglish
Pages (from-to)1695
Number of pages1
JournalInvestigative ophthalmology & visual science
Volume57
Issue number12
Publication statusPublished - 26 Sep 2016

Fingerprint

Ophthalmoscopes
Retina
Lighting
Equipment and Supplies
Artificial Eye
Webcasts
Avalanches
Light
Refractive Errors
Software

Cite this

Lochocki, B., Gambin-Regadera, A., Manzanera, S., Irles, E., Tajahuerce, E., Lancis, J., & Artal, P. (2016). Real-time single-pixel camera ophthalmoscope. Investigative ophthalmology & visual science, 57(12), 1695.
Lochocki, Benjamin ; Gambin-Regadera, Adrian ; Manzanera, Silvestre ; Irles, Esther ; Tajahuerce, Enrique ; Lancis, Jesús ; Artal, Pablo. / Real-time single-pixel camera ophthalmoscope. In: Investigative ophthalmology & visual science. 2016 ; Vol. 57, No. 12. pp. 1695.
@article{2523b725cac240018aabd0f01bc53718,
title = "Real-time single-pixel camera ophthalmoscope",
abstract = "Purpose: The examination of the retina is crucial for early detection of any unwanted alteration. Although there are different successful implementations of retinal imaging devices (ophthalmoscopes), new robust systems able to operate under many eye’s conditions may have a practical importance. Here, we introduce, as a proof of concept, a novel approach to image the retina in real time using a single-pixel camera. Methods: The Single-Pixel camera Ophthalmoscope (SPCO) is based on the concept of sequentially detecting the inner–product’s intensity of the object and a series of controlled base patterns. The image corresponding to the object is subsequently reconstructed computationally. The used configuration was a double-pass system that contains a digital micromirror device (DMD) creating a spatially coded illumination that were projected on the retina covering a field of around 16 degrees. The DMD was able to display series of Hadamard patterns with a rate up to 22 kHz. For each projected pattern, the reflected light coming from the retina is detected with an avalanche photomultiplier (single-point detector). After displaying a distinct number of patterns, an image of the retina is retrieved and displayed within our developed software interface in real-time. Results: Experimental results obtained using an artificial eye confirmed the viability of this approach. We were able to reconstruct images with a resolution up to 128 x 128 pixels. Furthermore, real-time video streaming with a frame-rate between 1 to 20 frames per second depending on the chosen resolution was produced. The use of sub-sampling techniques based in the spatial content of the images could either increase the frame rate or the image size. Since multiplexed illumination may offer a SNR improvement when compared to traditional approaches, this may reduce the light illuminating the eye. Conclusions: A novel approach to obtain images of the retina based in a single point detector has been proposed. The instrument (SPCO) operates in real-time and should be extremely tolerant to a variety of ocular conditions that typically degrade the images of the fundus, including large refractive errors or opacities. This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.",
author = "Benjamin Lochocki and Adrian Gambin-Regadera and Silvestre Manzanera and Esther Irles and Enrique Tajahuerce and Jes{\'u}s Lancis and Pablo Artal",
year = "2016",
month = "9",
day = "26",
language = "English",
volume = "57",
pages = "1695",
journal = "Investigative ophthalmology & visual science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology",
number = "12",

}

Lochocki, B, Gambin-Regadera, A, Manzanera, S, Irles, E, Tajahuerce, E, Lancis, J & Artal, P 2016, 'Real-time single-pixel camera ophthalmoscope' Investigative ophthalmology & visual science, vol. 57, no. 12, pp. 1695.

Real-time single-pixel camera ophthalmoscope. / Lochocki, Benjamin; Gambin-Regadera, Adrian; Manzanera, Silvestre; Irles, Esther; Tajahuerce, Enrique; Lancis, Jesús; Artal, Pablo.

In: Investigative ophthalmology & visual science, Vol. 57, No. 12, 26.09.2016, p. 1695.

Research output: Contribution to JournalMeeting AbstractOther research output

TY - JOUR

T1 - Real-time single-pixel camera ophthalmoscope

AU - Lochocki, Benjamin

AU - Gambin-Regadera, Adrian

AU - Manzanera, Silvestre

AU - Irles, Esther

AU - Tajahuerce, Enrique

AU - Lancis, Jesús

AU - Artal, Pablo

PY - 2016/9/26

Y1 - 2016/9/26

N2 - Purpose: The examination of the retina is crucial for early detection of any unwanted alteration. Although there are different successful implementations of retinal imaging devices (ophthalmoscopes), new robust systems able to operate under many eye’s conditions may have a practical importance. Here, we introduce, as a proof of concept, a novel approach to image the retina in real time using a single-pixel camera. Methods: The Single-Pixel camera Ophthalmoscope (SPCO) is based on the concept of sequentially detecting the inner–product’s intensity of the object and a series of controlled base patterns. The image corresponding to the object is subsequently reconstructed computationally. The used configuration was a double-pass system that contains a digital micromirror device (DMD) creating a spatially coded illumination that were projected on the retina covering a field of around 16 degrees. The DMD was able to display series of Hadamard patterns with a rate up to 22 kHz. For each projected pattern, the reflected light coming from the retina is detected with an avalanche photomultiplier (single-point detector). After displaying a distinct number of patterns, an image of the retina is retrieved and displayed within our developed software interface in real-time. Results: Experimental results obtained using an artificial eye confirmed the viability of this approach. We were able to reconstruct images with a resolution up to 128 x 128 pixels. Furthermore, real-time video streaming with a frame-rate between 1 to 20 frames per second depending on the chosen resolution was produced. The use of sub-sampling techniques based in the spatial content of the images could either increase the frame rate or the image size. Since multiplexed illumination may offer a SNR improvement when compared to traditional approaches, this may reduce the light illuminating the eye. Conclusions: A novel approach to obtain images of the retina based in a single point detector has been proposed. The instrument (SPCO) operates in real-time and should be extremely tolerant to a variety of ocular conditions that typically degrade the images of the fundus, including large refractive errors or opacities. This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

AB - Purpose: The examination of the retina is crucial for early detection of any unwanted alteration. Although there are different successful implementations of retinal imaging devices (ophthalmoscopes), new robust systems able to operate under many eye’s conditions may have a practical importance. Here, we introduce, as a proof of concept, a novel approach to image the retina in real time using a single-pixel camera. Methods: The Single-Pixel camera Ophthalmoscope (SPCO) is based on the concept of sequentially detecting the inner–product’s intensity of the object and a series of controlled base patterns. The image corresponding to the object is subsequently reconstructed computationally. The used configuration was a double-pass system that contains a digital micromirror device (DMD) creating a spatially coded illumination that were projected on the retina covering a field of around 16 degrees. The DMD was able to display series of Hadamard patterns with a rate up to 22 kHz. For each projected pattern, the reflected light coming from the retina is detected with an avalanche photomultiplier (single-point detector). After displaying a distinct number of patterns, an image of the retina is retrieved and displayed within our developed software interface in real-time. Results: Experimental results obtained using an artificial eye confirmed the viability of this approach. We were able to reconstruct images with a resolution up to 128 x 128 pixels. Furthermore, real-time video streaming with a frame-rate between 1 to 20 frames per second depending on the chosen resolution was produced. The use of sub-sampling techniques based in the spatial content of the images could either increase the frame rate or the image size. Since multiplexed illumination may offer a SNR improvement when compared to traditional approaches, this may reduce the light illuminating the eye. Conclusions: A novel approach to obtain images of the retina based in a single point detector has been proposed. The instrument (SPCO) operates in real-time and should be extremely tolerant to a variety of ocular conditions that typically degrade the images of the fundus, including large refractive errors or opacities. This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

M3 - Meeting Abstract

VL - 57

SP - 1695

JO - Investigative ophthalmology & visual science

JF - Investigative ophthalmology & visual science

SN - 0146-0404

IS - 12

ER -

Lochocki B, Gambin-Regadera A, Manzanera S, Irles E, Tajahuerce E, Lancis J et al. Real-time single-pixel camera ophthalmoscope. Investigative ophthalmology & visual science. 2016 Sep 26;57(12):1695.