Recent advances in capillary electrophoretic migration techniques for pharmaceutical analysis (2013–2015)

Sami El Deeb*, Hermann Wätzig, Deia Abd El-Hady, Cari Sänger-van de Griend, Gerhard K E Scriba

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

This review updates and follows-up a previous review by highlighting recent advancements regarding capillary electromigration methodologies and applications in pharmaceutical analysis. General approaches such as quality by design as well as sample injection methods and detection sensitivity are discussed. The separation and analysis of drug-related substances, chiral CE, and chiral CE-MS in addition to the determination of physicochemical constants are addressed. The advantages of applying affinity capillary electrophoresis in studying receptor–ligand interactions are highlighted. Finally, current aspects related to the analysis of biopharmaceuticals are reviewed. The present review covers the literature between January 2013 and December 2015.

Original languageEnglish
Pages (from-to)1591-1608
Number of pages18
JournalElectrophoresis
Volume37
Issue number12
DOIs
Publication statusPublished - 1 Jul 2016
Externally publishedYes

Keywords

  • Biopharmaceuticals
  • Capillary electrophoresis
  • Pharmaceutical analysis
  • Quantitation

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