Recent Advances in Palladium-Catalyzed Isocyanide Insertions

Jurriën W. Collet, Thomas R. Roose, Bram Weijers, Bert U.W. Maes, Eelco Ruijter, Romano V.A. Orru

Research output: Contribution to JournalReview articleAcademicpeer-review


Isocyanides have long been known as versatile chemical reagents in organic synthesis. Their ambivalent nature also allows them to function as a CO-substitute in palladium-catalyzed cross couplings. Over the past decades, isocyanides have emerged as practical and versatile C1 building blocks, whose inherent N-substitution allows for the rapid incorporation of nitrogeneous fragments in a wide variety of products. Recent developments in palladium catalyzed isocyanide insertion reactions have significantly expanded the scope and applicability of these imidoylative cross-couplings. This review highlights the advances made in this field over the past eight years.

Original languageEnglish
Article number4906
JournalMolecules (Basel, Switzerland)
Issue number21
Publication statusPublished - 23 Oct 2020


  • catalysis
  • heterocycles
  • insertion reactions
  • isocyanides
  • palladium


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