Abstract
Isocyanides have long been known as versatile chemical reagents in organic synthesis. Their ambivalent nature also allows them to function as a CO-substitute in palladium-catalyzed cross couplings. Over the past decades, isocyanides have emerged as practical and versatile C1 building blocks, whose inherent N-substitution allows for the rapid incorporation of nitrogeneous fragments in a wide variety of products. Recent developments in palladium catalyzed isocyanide insertion reactions have significantly expanded the scope and applicability of these imidoylative cross-couplings. This review highlights the advances made in this field over the past eight years.
Original language | English |
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Article number | 4906 |
Journal | Molecules (Basel, Switzerland) |
Volume | 25 |
Issue number | 21 |
DOIs | |
Publication status | Published - 23 Oct 2020 |
Keywords
- catalysis
- heterocycles
- insertion reactions
- isocyanides
- palladium