Abstract
Copyright © 2022 by Annual Reviews. All rights reserved.Axons receive extracellular signals that help to guide growth and synapse formation during development and to maintain neuronal function and survival during maturity. These signals relay information via cell surface receptors that can initiate local intracellular signaling at the site of binding, including local messenger RNA (mRNA) translation. Direct coupling of translational machinery to receptors provides an attractive way to activate this local mRNA translation and change the local proteome with high spatiotemporal resolution. Here, we first discuss the increasing evidence that different external stimuli trigger translation of specific subsets of mRNAs in axons via receptors and thus play a prominent role in various processes in both developing and mature neurons. We then discuss the receptor-mediated molecular mechanisms that regulate local mRNA translation with a focus on direct receptor-ribosome coupling. We advance the idea that receptor-ribosome coupling provides several advantages over other translational regulation mechanisms and is a common mechanism in cell communication.
| Original language | English |
|---|---|
| Pages (from-to) | 41-61 |
| Journal | Annual Review of Neuroscience |
| Volume | 45 |
| DOIs | |
| Publication status | Published - 1 Jul 2022 |
| Externally published | Yes |
Funding
We would like to thank Ginny G. Farías (Utrecht University) for critically reading the manuscript and providing valuable comments.
| Funders | Funder number |
|---|---|
| Universiteit Utrecht |