Red Light-Triggered CO Release from Mn2(CO)10 Using Triplet Sensitization in Polymer Nonwoven Fabrics

S.H.C. Askes; G.U. Reddy; R. Wyrwa; S. Bonnet; A. Schiller

doi:10.1021/jacs.7b07427

Red Light-Triggered CO Release from Mn2(CO)10 Using Triplet Sensitization in Polymer Nonwoven Fabrics

S.H.C. Askes, G.U. Reddy, R. Wyrwa, S. Bonnet, A. Schiller

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

© 2017 American Chemical Society.Applicability of phototherapeutic CO-releasing molecules (photoCORMs) is limited because they are activated by harmful and poorly tissue-penetrating near-ultraviolet light. Here, a strategy is demonstrated to activate classical photoCORM Mn2(CO)10 using red light (635 nm). By mixing in solution a triplet photosensitizer (PS) with the photoCORM and shining red light, energy transfer occurs from triplet excited-state 3PS∗ to a photolabile triplet state of Mn2(CO)10, which, like under near-UV irradiation, led to complete release of carbonyls. Crucially, such "triplet-sensitized CO-release" occurred in solid-state materials: when PS and Mn2(CO)10 were embedded in electrospun nonwoven fabrics, CO was liberated upon irradiation with low-intensity red light (≤36 mW 635 nm).

Original language	English
Pages (from-to)	15292-15295
Journal	Journal of the American Chemical Society
Volume	139
Issue number	43
DOIs	https://doi.org/10.1021/jacs.7b07427
Publication status	Published - 1 Nov 2017
Externally published	Yes

Funding

This work was supported by a grant from German Research Foundation (DFG) for supporting FOR 1738 (grant number SCHI 1175/2-2). A.S. thanks the DFG for a Heisenberg fellowship (grant numbers SCHI 1175/4-1 and SCHI 1175/5-1). ERC is ackowledged for a Starting grant to S.B. NWO is kindly ackowledged for financial support of S.B. via a VIDI grant.

Funders	Funder number
Deutsche Forschungsgemeinschaft	SCHI 1175/2-2, SCHI 1175/5-1, SCHI 1175/4-1

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title = "Red Light-Triggered CO Release from Mn2(CO)10 Using Triplet Sensitization in Polymer Nonwoven Fabrics",

abstract = "{\textcopyright} 2017 American Chemical Society.Applicability of phototherapeutic CO-releasing molecules (photoCORMs) is limited because they are activated by harmful and poorly tissue-penetrating near-ultraviolet light. Here, a strategy is demonstrated to activate classical photoCORM Mn2(CO)10 using red light (635 nm). By mixing in solution a triplet photosensitizer (PS) with the photoCORM and shining red light, energy transfer occurs from triplet excited-state 3PS∗ to a photolabile triplet state of Mn2(CO)10, which, like under near-UV irradiation, led to complete release of carbonyls. Crucially, such {"}triplet-sensitized CO-release{"} occurred in solid-state materials: when PS and Mn2(CO)10 were embedded in electrospun nonwoven fabrics, CO was liberated upon irradiation with low-intensity red light (≤36 mW 635 nm).",

author = "S.H.C. Askes and G.U. Reddy and R. Wyrwa and S. Bonnet and A. Schiller",

year = "2017",

month = nov,

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doi = "10.1021/jacs.7b07427",

language = "English",

volume = "139",

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journal = "Journal of the American Chemical Society",

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TY - JOUR

T1 - Red Light-Triggered CO Release from Mn2(CO)10 Using Triplet Sensitization in Polymer Nonwoven Fabrics

AU - Askes, S.H.C.

AU - Reddy, G.U.

AU - Wyrwa, R.

AU - Bonnet, S.

AU - Schiller, A.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - © 2017 American Chemical Society.Applicability of phototherapeutic CO-releasing molecules (photoCORMs) is limited because they are activated by harmful and poorly tissue-penetrating near-ultraviolet light. Here, a strategy is demonstrated to activate classical photoCORM Mn2(CO)10 using red light (635 nm). By mixing in solution a triplet photosensitizer (PS) with the photoCORM and shining red light, energy transfer occurs from triplet excited-state 3PS∗ to a photolabile triplet state of Mn2(CO)10, which, like under near-UV irradiation, led to complete release of carbonyls. Crucially, such "triplet-sensitized CO-release" occurred in solid-state materials: when PS and Mn2(CO)10 were embedded in electrospun nonwoven fabrics, CO was liberated upon irradiation with low-intensity red light (≤36 mW 635 nm).

AB - © 2017 American Chemical Society.Applicability of phototherapeutic CO-releasing molecules (photoCORMs) is limited because they are activated by harmful and poorly tissue-penetrating near-ultraviolet light. Here, a strategy is demonstrated to activate classical photoCORM Mn2(CO)10 using red light (635 nm). By mixing in solution a triplet photosensitizer (PS) with the photoCORM and shining red light, energy transfer occurs from triplet excited-state 3PS∗ to a photolabile triplet state of Mn2(CO)10, which, like under near-UV irradiation, led to complete release of carbonyls. Crucially, such "triplet-sensitized CO-release" occurred in solid-state materials: when PS and Mn2(CO)10 were embedded in electrospun nonwoven fabrics, CO was liberated upon irradiation with low-intensity red light (≤36 mW 635 nm).

U2 - 10.1021/jacs.7b07427

DO - 10.1021/jacs.7b07427

M3 - Article

SN - 0002-7863

VL - 139

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EP - 15295

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 43

ER -

Red Light-Triggered CO Release from Mn2(CO)10 Using Triplet Sensitization in Polymer Nonwoven Fabrics

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