Reduced anterior cingulate and orbitofrontal volumes in child abuse-related complex PTSD

K. Thomaes, E. Dorrepaal, P.J. Draijer, M.B. de Ruiter, A.J.L.M. van Balkom, J.H. Smit, D.J. Veltman

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Objective: Classic posttraumatic stress disorder (PTSD) is associated with smaller hippocampus, amygdala, and anterior cingulate cortex (ACC) volumes. We investigated whether child abuse-related complex PTSD - a severe form of PTSD with affect dysregulation and high comorbidity-showed similar brain volume reductions. Method: We used voxel-based morphometry to measure gray matter concentrations in referred outpatients with child abuse-related complex PTSD (n = 31) compared to matched healthy nontraumatized controls (n = 28). Complex PTSD was diagnosed using the Structured Clinical Interview for DSM-IV-TR and the Structured Clinical Interview for Disorders of Extreme Stress. All respondents were scanned on a 1.5-T magnetic resonance system at the VU Medical Center, Amsterdam, The Netherlands, between September 2005 and February 2006. Results: As was hypothesized, patients with child abuse-related complex PTSD showed reductions in gray matter concentration in right hippocampus (P
    Original languageEnglish
    Pages (from-to)1636-1644
    JournalJournal of Clinical Psychiatry
    Volume71
    Issue number12
    DOIs
    Publication statusPublished - 2010

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