Reduced anterior cingulate and orbitofrontal volumes in child abuse-related complex PTSD

K. Thomaes; E. Dorrepaal; P.J. Draijer; M.B. de Ruiter; A.J.L.M. van Balkom; J.H. Smit; D.J. Veltman

doi:10.4088/JCP.08m04754blu

Reduced anterior cingulate and orbitofrontal volumes in child abuse-related complex PTSD

K. Thomaes
, E. Dorrepaal
, P.J. Draijer
, M.B. de Ruiter
, A.J.L.M. van Balkom
, J.H. Smit
, D.J. Veltman

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Objective: Classic posttraumatic stress disorder (PTSD) is associated with smaller hippocampus, amygdala, and anterior cingulate cortex (ACC) volumes. We investigated whether child abuse-related complex PTSD - a severe form of PTSD with affect dysregulation and high comorbidity-showed similar brain volume reductions. Method: We used voxel-based morphometry to measure gray matter concentrations in referred outpatients with child abuse-related complex PTSD (n = 31) compared to matched healthy nontraumatized controls (n = 28). Complex PTSD was diagnosed using the Structured Clinical Interview for DSM-IV-TR and the Structured Clinical Interview for Disorders of Extreme Stress. All respondents were scanned on a 1.5-T magnetic resonance system at the VU Medical Center, Amsterdam, The Netherlands, between September 2005 and February 2006. Results: As was hypothesized, patients with child abuse-related complex PTSD showed reductions in gray matter concentration in right hippocampus (P

Original language	English
Pages (from-to)	1636-1644
Journal	Journal of Clinical Psychiatry
Volume	71
Issue number	12
DOIs	https://doi.org/10.4088/JCP.08m04754blu
Publication status	Published - 2010

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10.4088/JCP.08m04754blu

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title = "Reduced anterior cingulate and orbitofrontal volumes in child abuse-related complex PTSD",

abstract = "Objective: Classic posttraumatic stress disorder (PTSD) is associated with smaller hippocampus, amygdala, and anterior cingulate cortex (ACC) volumes. We investigated whether child abuse-related complex PTSD - a severe form of PTSD with affect dysregulation and high comorbidity-showed similar brain volume reductions. Method: We used voxel-based morphometry to measure gray matter concentrations in referred outpatients with child abuse-related complex PTSD (n = 31) compared to matched healthy nontraumatized controls (n = 28). Complex PTSD was diagnosed using the Structured Clinical Interview for DSM-IV-TR and the Structured Clinical Interview for Disorders of Extreme Stress. All respondents were scanned on a 1.5-T magnetic resonance system at the VU Medical Center, Amsterdam, The Netherlands, between September 2005 and February 2006. Results: As was hypothesized, patients with child abuse-related complex PTSD showed reductions in gray matter concentration in right hippocampus (P",

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doi = "10.4088/JCP.08m04754blu",

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T1 - Reduced anterior cingulate and orbitofrontal volumes in child abuse-related complex PTSD

AU - Thomaes, K.

AU - Dorrepaal, E.

AU - Draijer, P.J.

AU - de Ruiter, M.B.

AU - van Balkom, A.J.L.M.

AU - Smit, J.H.

AU - Veltman, D.J.

PY - 2010

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N2 - Objective: Classic posttraumatic stress disorder (PTSD) is associated with smaller hippocampus, amygdala, and anterior cingulate cortex (ACC) volumes. We investigated whether child abuse-related complex PTSD - a severe form of PTSD with affect dysregulation and high comorbidity-showed similar brain volume reductions. Method: We used voxel-based morphometry to measure gray matter concentrations in referred outpatients with child abuse-related complex PTSD (n = 31) compared to matched healthy nontraumatized controls (n = 28). Complex PTSD was diagnosed using the Structured Clinical Interview for DSM-IV-TR and the Structured Clinical Interview for Disorders of Extreme Stress. All respondents were scanned on a 1.5-T magnetic resonance system at the VU Medical Center, Amsterdam, The Netherlands, between September 2005 and February 2006. Results: As was hypothesized, patients with child abuse-related complex PTSD showed reductions in gray matter concentration in right hippocampus (P

AB - Objective: Classic posttraumatic stress disorder (PTSD) is associated with smaller hippocampus, amygdala, and anterior cingulate cortex (ACC) volumes. We investigated whether child abuse-related complex PTSD - a severe form of PTSD with affect dysregulation and high comorbidity-showed similar brain volume reductions. Method: We used voxel-based morphometry to measure gray matter concentrations in referred outpatients with child abuse-related complex PTSD (n = 31) compared to matched healthy nontraumatized controls (n = 28). Complex PTSD was diagnosed using the Structured Clinical Interview for DSM-IV-TR and the Structured Clinical Interview for Disorders of Extreme Stress. All respondents were scanned on a 1.5-T magnetic resonance system at the VU Medical Center, Amsterdam, The Netherlands, between September 2005 and February 2006. Results: As was hypothesized, patients with child abuse-related complex PTSD showed reductions in gray matter concentration in right hippocampus (P

U2 - 10.4088/JCP.08m04754blu

DO - 10.4088/JCP.08m04754blu

M3 - Article

SN - 0160-6689

VL - 71

SP - 1636

EP - 1644

JO - Journal of Clinical Psychiatry

JF - Journal of Clinical Psychiatry

IS - 12

ER -

Reduced anterior cingulate and orbitofrontal volumes in child abuse-related complex PTSD

Abstract

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