Reduced context effects on retrieval in first-episode schizophrenia

L.M. Talamini, L. Haan, D.H. Nieman, D.H. Linszen, M. Meeter

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Abstract

Background: A recent modeling study by the authors predicted that contextual information is poorly integrated into episodic representations in schizophrenia, and that this is a main cause of the retrieval deficits seen in schizophrenia. & Methodology/Principal Findings: We have tested this prediction in patients with first-episode schizophrenia and matched controls. The benefit from contextual cues in retrieval was strongly reduced in patients. On the other hand, retrieval based on item cues was spared. & Conclusions/Significance: These results suggest that reduced integration of context information into episodic representations is a core deficit in schizophrenia and one of the main causes of episodic memory impairment. © 2010 Talamini.
Original languageEnglish
Pages (from-to)e10356
Number of pages7
JournalPLoS ONE
Volume5
DOIs
Publication statusPublished - 2010

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