Reduced hexokinase II impairs muscle function 2 weeks after ischemia-reperfusion through increased cell necrosis and fibrosis

K.M. Smeele, O. Eerbeek, G. Schaart, A. Koeman, R. Bezemer, J.K. Nelson, C. Ince, R. Nederhof, M. Boek, M. Laakso, A. de Haan, M.R. Drost, M.W. Hollman, C.J. Zuurbier

    Research output: Contribution to JournalArticleAcademicpeer-review

    24 Downloads (Pure)

    Abstract

    We previously demonstrated that hexokinase (HK) II plays a key role in the pathophysiology of ischemia-reperfusion (I/R) injury of the heart (Smeele et al. Circ Res 108: 1165-1169, 2011; Wu et al. Circ Res 108: 60-69, 2011). However, it is unknown whether HKII also plays a key role in I/R injury and healing thereafter in skeletal muscle, and if so, through which mechanisms. We used male wild-type (WT) and heterozygous HKII knockout mice (HKII
    Original languageEnglish
    Pages (from-to)608-618
    JournalJournal of Applied Physiology (1985)
    Volume113
    DOIs
    Publication statusPublished - 2012

    Fingerprint

    Dive into the research topics of 'Reduced hexokinase II impairs muscle function 2 weeks after ischemia-reperfusion through increased cell necrosis and fibrosis'. Together they form a unique fingerprint.

    Cite this