Reduced hexokinase II impairs muscle function 2 weeks after ischemia-reperfusion through increased cell necrosis and fibrosis

K.M. Smeele; O. Eerbeek; G. Schaart; A. Koeman; R. Bezemer; J.K. Nelson; C. Ince; R. Nederhof; M. Boek; M. Laakso; A. de Haan; M.R. Drost; M.W. Hollman; C.J. Zuurbier

doi:10.1152/japplphysiol.01494.2011

Reduced hexokinase II impairs muscle function 2 weeks after ischemia-reperfusion through increased cell necrosis and fibrosis

K.M. Smeele
, O. Eerbeek
, G. Schaart
, A. Koeman
, R. Bezemer
, J.K. Nelson
, C. Ince
, R. Nederhof
, M. Boek
, M. Laakso
, A. de Haan
, M.R. Drost
, M.W. Hollman
, C.J. Zuurbier

Research output: Contribution to Journal › Article › Academic › peer-review

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Abstract

We previously demonstrated that hexokinase (HK) II plays a key role in the pathophysiology of ischemia-reperfusion (I/R) injury of the heart (Smeele et al. Circ Res 108: 1165-1169, 2011; Wu et al. Circ Res 108: 60-69, 2011). However, it is unknown whether HKII also plays a key role in I/R injury and healing thereafter in skeletal muscle, and if so, through which mechanisms. We used male wild-type (WT) and heterozygous HKII knockout mice (HKII

Original language	English
Pages (from-to)	608-618
Journal	Journal of Applied Physiology (1985)
Volume	113
DOIs	https://doi.org/10.1152/japplphysiol.01494.2011
Publication status	Published - 2012

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Smeele, K. M., Eerbeek, O., Schaart, G., Koeman, A., Bezemer, R., Nelson, J. K., Ince, C., Nederhof, R., Boek, M., Laakso, M., de Haan, A., Drost, M. R., Hollman, M. W., & Zuurbier, C. J. (2012). Reduced hexokinase II impairs muscle function 2 weeks after ischemia-reperfusion through increased cell necrosis and fibrosis. Journal of Applied Physiology (1985), 113, 608-618. https://doi.org/10.1152/japplphysiol.01494.2011

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title = "Reduced hexokinase II impairs muscle function 2 weeks after ischemia-reperfusion through increased cell necrosis and fibrosis",

abstract = "We previously demonstrated that hexokinase (HK) II plays a key role in the pathophysiology of ischemia-reperfusion (I/R) injury of the heart (Smeele et al. Circ Res 108: 1165-1169, 2011; Wu et al. Circ Res 108: 60-69, 2011). However, it is unknown whether HKII also plays a key role in I/R injury and healing thereafter in skeletal muscle, and if so, through which mechanisms. We used male wild-type (WT) and heterozygous HKII knockout mice (HKII",

author = "K.M. Smeele and O. Eerbeek and G. Schaart and A. Koeman and R. Bezemer and J.K. Nelson and C. Ince and R. Nederhof and M. Boek and M. Laakso and \{de Haan\}, A. and M.R. Drost and M.W. Hollman and C.J. Zuurbier",

year = "2012",

doi = "10.1152/japplphysiol.01494.2011",

language = "English",

volume = "113",

pages = "608--618",

journal = "Journal of Applied Physiology (1985)",

issn = "8750-7587",

publisher = "American Physiological Society",

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Smeele, KM, Eerbeek, O, Schaart, G, Koeman, A, Bezemer, R, Nelson, JK, Ince, C, Nederhof, R, Boek, M, Laakso, M, de Haan, A, Drost, MR, Hollman, MW & Zuurbier, CJ 2012, 'Reduced hexokinase II impairs muscle function 2 weeks after ischemia-reperfusion through increased cell necrosis and fibrosis', Journal of Applied Physiology (1985), vol. 113, pp. 608-618. https://doi.org/10.1152/japplphysiol.01494.2011

TY - JOUR

T1 - Reduced hexokinase II impairs muscle function 2 weeks after ischemia-reperfusion through increased cell necrosis and fibrosis

AU - Smeele, K.M.

AU - Eerbeek, O.

AU - Schaart, G.

AU - Koeman, A.

AU - Bezemer, R.

AU - Nelson, J.K.

AU - Ince, C.

AU - Nederhof, R.

AU - Boek, M.

AU - Laakso, M.

AU - de Haan, A.

AU - Drost, M.R.

AU - Hollman, M.W.

AU - Zuurbier, C.J.

PY - 2012

Y1 - 2012

N2 - We previously demonstrated that hexokinase (HK) II plays a key role in the pathophysiology of ischemia-reperfusion (I/R) injury of the heart (Smeele et al. Circ Res 108: 1165-1169, 2011; Wu et al. Circ Res 108: 60-69, 2011). However, it is unknown whether HKII also plays a key role in I/R injury and healing thereafter in skeletal muscle, and if so, through which mechanisms. We used male wild-type (WT) and heterozygous HKII knockout mice (HKII

AB - We previously demonstrated that hexokinase (HK) II plays a key role in the pathophysiology of ischemia-reperfusion (I/R) injury of the heart (Smeele et al. Circ Res 108: 1165-1169, 2011; Wu et al. Circ Res 108: 60-69, 2011). However, it is unknown whether HKII also plays a key role in I/R injury and healing thereafter in skeletal muscle, and if so, through which mechanisms. We used male wild-type (WT) and heterozygous HKII knockout mice (HKII

U2 - 10.1152/japplphysiol.01494.2011

DO - 10.1152/japplphysiol.01494.2011

M3 - Article

SN - 8750-7587

VL - 113

SP - 608

EP - 618

JO - Journal of Applied Physiology (1985)

JF - Journal of Applied Physiology (1985)

ER -

Reduced hexokinase II impairs muscle function 2 weeks after ischemia-reperfusion through increased cell necrosis and fibrosis

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