Reduced parahippocampal and lateral temporal GABA(A)-[C-11]flumazenil binding in major depression: preliminary results

U.M.H. Klumpers, D.J. Veltman, M.L. Drent, R. Boellaard, E.F.I. Comans, G. Meynen, A.A. Lammertsma, W.J.G. Hoogendijk

Research output: Contribution to JournalArticleAcademicpeer-review


Purpose: Major depressive disorder (MDD) has been related to both a dysfunctional γ-amino butyric acid (GABA) system and to hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA). Although GABA has been suggested to inhibit HPA axis activity, their relationship has never been studied at the level of the central GABA
Original languageEnglish
Pages (from-to)565-574
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number3
Publication statusPublished - 2010


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