Political science as a discipline has largely ignored research regulatory policies associated with institutional review boards (IRBs). Many political scientists-especially those in the senior ranks-are either oblivious to the existence of IRBs or actively decide to sidestep them by not submitting their proposals for review. Based on research conducted since 2004, we hold that APSA members at all ranks of the profession, along with political scientists worldwide, need to be concerned, not to say alarmed, about IRB policy. Why this sense of urgency, and why now? Copyright © The American Political Science Association 2008.