Regaining Cognitive Control: An Adaptive Computational Model Involving Neural Correlates of Stress, Control and Intervention

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review

Abstract

Apart from various other neural and hormonal changes caused by stress, frequent and long-term activation of the hypothalamus–pituitary–adrenal (HPA) axis in response to stress leads in an adaptive manner to the inadequacy of the stress response system. This leads to a cognitive dysfunction where the subject is no more able to downregulate his or her stress due to the atrophy in the hippocampus and hypertrophy in the amygdala. These atrophies can be dealt with by antidepressant treatment or psychological treatments like cognitive and behavioural therapies. In this paper, an adaptive neuroscience-based computational network model is introduced which demonstrates such a cognitive dysfunction due to a long-term stressor and regaining of the cognitive abilities through a cognitive behavioural therapy: Mindfulness-Based Cognitive Therapy (MBCT). Simulation results are reported for the model which demonstrates the adaptivity as well as the dynamic interaction of the involved brain areas in the phenomenon.
Original languageEnglish
Title of host publicationProc. of the 21th International Conference on Computational Science, ICCS'21
EditorsM. Paszynski, D. Kranzlmüller, V.V. Krzhizhanovskaya, J.J. Dongarra, P.M.A. Sloot
PublisherSpringer Nature Switzerland AG
Pages556-569
ISBN (Print)9783030779665
DOIs
Publication statusPublished - 2021
Event21st International Conference on Computational Science, ICCS 2021 - Virtual, Online
Duration: 16 Jun 202118 Jun 2021

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference21st International Conference on Computational Science, ICCS 2021
CityVirtual, Online
Period16/06/2118/06/21

Fingerprint

Dive into the research topics of 'Regaining Cognitive Control: An Adaptive Computational Model Involving Neural Correlates of Stress, Control and Intervention'. Together they form a unique fingerprint.

Cite this