Regaining Cognitive Control: An Adaptive Computational Model Involving Neural Correlates of Stress, Control and Intervention

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Abstract

Apart from various other neural and hormonal changes caused by stress, frequent and long-term activation of the hypothalamus–pituitary–adrenal (HPA) axis in response to stress leads in an adaptive manner to the inadequacy of the stress response system. This leads to a cognitive dysfunction where the subject is no more able to downregulate his or her stress due to the atrophy in the hippocampus and hypertrophy in the amygdala. These atrophies can be dealt with by antidepressant treatment or psychological treatments like cognitive and behavioural therapies. In this paper, an adaptive neuroscience-based computational network model is introduced which demonstrates such a cognitive dysfunction due to a long-term stressor and regaining of the cognitive abilities through a cognitive behavioural therapy: Mindfulness-Based Cognitive Therapy (MBCT). Simulation results are reported for the model which demonstrates the adaptivity as well as the dynamic interaction of the involved brain areas in the phenomenon.
Original languageEnglish
Title of host publicationComputational Science – ICCS 2021
Subtitle of host publication21st International Conference, Krakow, Poland, June 16–18, 2021, Proceedings, Part III
EditorsMaciej Paszynski, Dieter Kranzlmüller, Valeria V. Krzhizhanovskaya, Jack J. Dongarra, Peter M.A. Sloot
PublisherSpringer Nature Switzerland AG
Pages556-569
Number of pages15
Volume3
ISBN (Electronic)9783030779672
ISBN (Print)9783030779665
DOIs
Publication statusPublished - 2021
Event21st International Conference on Computational Science, ICCS 2021 - Virtual, Online
Duration: 16 Jun 202118 Jun 2021

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume12744 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference21st International Conference on Computational Science, ICCS 2021
CityVirtual, Online
Period16/06/2118/06/21

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