Regenerative Medicine For Alveolar Cleft Treatment

Chapter 1 explains a general introduction of the thesis. in Chapter 2, we first conducted a systematic literature review and meta-analysis to evaluate the available regenerative graft materials for maxillary sinus augmentation in randomized clinical trials, as this is the most prevalent clinical model for bone augmentation in the craniofacial region. In Chapters 3 and 4, systematic reviews and meta-analyses were conducted on stem cell-based tissue engineering of cleft defects in animal models (Chapter 3) and on regenerative alveolar graft materials in clinical trials (Chapter 4) to provide a comprehensive overview of what has been accomplished in alveolar cleft repair utilizing regenerative medicine approaches. Chapter 5 presents a study protocol for a pilot randomized controlled trial involving Polyphosphate (polyP) for alveolar cleft repair. In Chapter 6, we conducted a clinical trial safety and feasibility study on the use of Polyphosphate (PolyP) in repairing alveolar clefts. In Chapter 7, a prospective study conducted in Indonesia investigated the impact of patient-related variables on intraoperative blood loss during double opposing Z-plasty, Furlow palatoplasty, and buccal fat pad coverage. A prospective clinical trial protocol utilizing micro-fragmented fat (MFAT) and BCP has been proposed for alveolar cleft repair (Chapter 8) in light of the observed benefit of using adipose tissue for bone regeneration. Chapter 9 discusses the outcomes of the topics covered in this thesis and suggestions for future research. Finally, a summary of this thesis in English is provided.