Region-specific adaptations in determinants of rat skeletal muscle oxygenation to chronic hypoxia

R.C.I. Wust, R.T. Jaspers, A.F. van Heijst, M.T.E. Hopman, L.J. Hoofd, W.J. van der Laarse, H. Degens

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Chronic exposure to hypoxia is associated with muscle atrophy (i.e., a reduction in muscle fiber cross-sectional area), reduced oxidative capacity, and capillary growth. It is controversial whether these changes are muscle and fiber type specific. We hypothesized that different regions of the same muscle would also respond differently to chronic hypoxia. To investigate this, we compared the deep (oxidative) and superficial (glycolytic) region of the plantaris muscle of eight male rats exposed to 4 wk of hypobaric hypoxia (410 mmHg, PO
    Original languageEnglish
    Pages (from-to)h364-374
    JournalAmerican Journal of Physiology. Heart and Circulatory Physiology
    Volume297
    Issue number1
    DOIs
    Publication statusPublished - 2009

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