TY - JOUR
T1 - Region-specific adaptations in determinants of rat skeletal muscle oxygenation to chronic hypoxia
AU - Wust, R.C.I.
AU - Jaspers, R.T.
AU - van Heijst, A.F.
AU - Hopman, M.T.E.
AU - Hoofd, L.J.
AU - van der Laarse, W.J.
AU - Degens, H.
PY - 2009
Y1 - 2009
N2 - Chronic exposure to hypoxia is associated with muscle atrophy (i.e., a reduction in muscle fiber cross-sectional area), reduced oxidative capacity, and capillary growth. It is controversial whether these changes are muscle and fiber type specific. We hypothesized that different regions of the same muscle would also respond differently to chronic hypoxia. To investigate this, we compared the deep (oxidative) and superficial (glycolytic) region of the plantaris muscle of eight male rats exposed to 4 wk of hypobaric hypoxia (410 mmHg, PO
AB - Chronic exposure to hypoxia is associated with muscle atrophy (i.e., a reduction in muscle fiber cross-sectional area), reduced oxidative capacity, and capillary growth. It is controversial whether these changes are muscle and fiber type specific. We hypothesized that different regions of the same muscle would also respond differently to chronic hypoxia. To investigate this, we compared the deep (oxidative) and superficial (glycolytic) region of the plantaris muscle of eight male rats exposed to 4 wk of hypobaric hypoxia (410 mmHg, PO
U2 - 10.1152/ajpheart.00272.2009
DO - 10.1152/ajpheart.00272.2009
M3 - Article
SN - 0363-6135
VL - 297
SP - h364-374
JO - American Journal of Physiology. Heart and Circulatory Physiology
JF - American Journal of Physiology. Heart and Circulatory Physiology
IS - 1
ER -