Regional sympathetic denervation affects the relation between canine local myocardial blood flow and oxygen consumption

D. Alders, R.N. Cornelussen, F.W. Prinzen, P.A.C. Specht, M.J. Noble, A.J. Drake-Holland, F.J.J. de Kanter, J.P. van der Beek

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Myocardial blood flow and oxygen consumption are heterogeneously distributed. Perfusion and myocardial oxygen consumption are closely correlated in the normal heart. It is unknown how this metabolism-perfusion relation is influenced by sympathetic denervation. We investigated this question in seven chloralose-anaesthetized dogs, 3-4 weeks after regional sympathetic denervation of the left circumflex coronary artery area of supply of the left ventricle. Measurements were made of local myocardial blood flow (MBF, in ml min
Original languageEnglish
Pages (from-to)541-548
JournalExperimental Physiology
Volume92
DOIs
Publication statusPublished - 2007

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