Regional sympathetic denervation affects the relation between canine local myocardial blood flow and oxygen consumption

D. Alders; R.N. Cornelussen; F.W. Prinzen; P.A.C. Specht; M.J. Noble; A.J. Drake-Holland; F.J.J. de Kanter; J.P. van der Beek

doi:10.1113/expphysiol.2006.036228

Regional sympathetic denervation affects the relation between canine local myocardial blood flow and oxygen consumption

D. Alders, R.N. Cornelussen, F.W. Prinzen, P.A.C. Specht, M.J. Noble, A.J. Drake-Holland, F.J.J. de Kanter, J.P. van der Beek

Organic Chemistry

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Myocardial blood flow and oxygen consumption are heterogeneously distributed. Perfusion and myocardial oxygen consumption are closely correlated in the normal heart. It is unknown how this metabolism-perfusion relation is influenced by sympathetic denervation. We investigated this question in seven chloralose-anaesthetized dogs, 3-4 weeks after regional sympathetic denervation of the left circumflex coronary artery area of supply of the left ventricle. Measurements were made of local myocardial blood flow (MBF, in ml min

Original language	English
Pages (from-to)	541-548
Journal	Experimental Physiology
Volume	92
DOIs	https://doi.org/10.1113/expphysiol.2006.036228
Publication status	Published - 2007

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title = "Regional sympathetic denervation affects the relation between canine local myocardial blood flow and oxygen consumption",

abstract = "Myocardial blood flow and oxygen consumption are heterogeneously distributed. Perfusion and myocardial oxygen consumption are closely correlated in the normal heart. It is unknown how this metabolism-perfusion relation is influenced by sympathetic denervation. We investigated this question in seven chloralose-anaesthetized dogs, 3-4 weeks after regional sympathetic denervation of the left circumflex coronary artery area of supply of the left ventricle. Measurements were made of local myocardial blood flow (MBF, in ml min",

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AU - Alders, D.

AU - Cornelussen, R.N.

AU - Prinzen, F.W.

AU - Specht, P.A.C.

AU - Noble, M.J.

AU - Drake-Holland, A.J.

AU - de Kanter, F.J.J.

AU - van der Beek, J.P.

PY - 2007

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AB - Myocardial blood flow and oxygen consumption are heterogeneously distributed. Perfusion and myocardial oxygen consumption are closely correlated in the normal heart. It is unknown how this metabolism-perfusion relation is influenced by sympathetic denervation. We investigated this question in seven chloralose-anaesthetized dogs, 3-4 weeks after regional sympathetic denervation of the left circumflex coronary artery area of supply of the left ventricle. Measurements were made of local myocardial blood flow (MBF, in ml min

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DO - 10.1113/expphysiol.2006.036228

M3 - Article

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VL - 92

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JO - Experimental Physiology

JF - Experimental Physiology

ER -

Regional sympathetic denervation affects the relation between canine local myocardial blood flow and oxygen consumption

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