Regional sympathetic denervation affects the relation between canine local myocardial blood flow and oxygen consumption

D. Alders, R.N. Cornelussen, F.W. Prinzen, P.A.C. Specht, M.J. Noble, A.J. Drake-Holland, F.J.J. de Kanter, J.P. van der Beek

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Myocardial blood flow and oxygen consumption are heterogeneously distributed. Perfusion and myocardial oxygen consumption are closely correlated in the normal heart. It is unknown how this metabolism-perfusion relation is influenced by sympathetic denervation. We investigated this question in seven chloralose-anaesthetized dogs, 3-4 weeks after regional sympathetic denervation of the left circumflex coronary artery area of supply of the left ventricle. Measurements were made of local myocardial blood flow (MBF, in ml min
Original languageEnglish
Pages (from-to)541-548
JournalExperimental Physiology
Volume92
DOIs
Publication statusPublished - 2007

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Sympathectomy
Oxygen Consumption
Canidae
Perfusion
Chloralose
Heart Ventricles
Coronary Vessels
Dogs

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Alders, D., Cornelussen, R. N., Prinzen, F. W., Specht, P. A. C., Noble, M. J., Drake-Holland, A. J., ... van der Beek, J. P. (2007). Regional sympathetic denervation affects the relation between canine local myocardial blood flow and oxygen consumption. Experimental Physiology, 92, 541-548. https://doi.org/10.1113/expphysiol.2006.036228
Alders, D. ; Cornelussen, R.N. ; Prinzen, F.W. ; Specht, P.A.C. ; Noble, M.J. ; Drake-Holland, A.J. ; de Kanter, F.J.J. ; van der Beek, J.P. / Regional sympathetic denervation affects the relation between canine local myocardial blood flow and oxygen consumption. In: Experimental Physiology. 2007 ; Vol. 92. pp. 541-548.
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abstract = "Myocardial blood flow and oxygen consumption are heterogeneously distributed. Perfusion and myocardial oxygen consumption are closely correlated in the normal heart. It is unknown how this metabolism-perfusion relation is influenced by sympathetic denervation. We investigated this question in seven chloralose-anaesthetized dogs, 3-4 weeks after regional sympathetic denervation of the left circumflex coronary artery area of supply of the left ventricle. Measurements were made of local myocardial blood flow (MBF, in ml min",
author = "D. Alders and R.N. Cornelussen and F.W. Prinzen and P.A.C. Specht and M.J. Noble and A.J. Drake-Holland and {de Kanter}, F.J.J. and {van der Beek}, J.P.",
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Alders, D, Cornelussen, RN, Prinzen, FW, Specht, PAC, Noble, MJ, Drake-Holland, AJ, de Kanter, FJJ & van der Beek, JP 2007, 'Regional sympathetic denervation affects the relation between canine local myocardial blood flow and oxygen consumption' Experimental Physiology, vol. 92, pp. 541-548. https://doi.org/10.1113/expphysiol.2006.036228

Regional sympathetic denervation affects the relation between canine local myocardial blood flow and oxygen consumption. / Alders, D.; Cornelussen, R.N.; Prinzen, F.W.; Specht, P.A.C.; Noble, M.J.; Drake-Holland, A.J.; de Kanter, F.J.J.; van der Beek, J.P.

In: Experimental Physiology, Vol. 92, 2007, p. 541-548.

Research output: Contribution to JournalArticleAcademicpeer-review

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AU - Cornelussen, R.N.

AU - Prinzen, F.W.

AU - Specht, P.A.C.

AU - Noble, M.J.

AU - Drake-Holland, A.J.

AU - de Kanter, F.J.J.

AU - van der Beek, J.P.

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AB - Myocardial blood flow and oxygen consumption are heterogeneously distributed. Perfusion and myocardial oxygen consumption are closely correlated in the normal heart. It is unknown how this metabolism-perfusion relation is influenced by sympathetic denervation. We investigated this question in seven chloralose-anaesthetized dogs, 3-4 weeks after regional sympathetic denervation of the left circumflex coronary artery area of supply of the left ventricle. Measurements were made of local myocardial blood flow (MBF, in ml min

U2 - 10.1113/expphysiol.2006.036228

DO - 10.1113/expphysiol.2006.036228

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JO - Experimental Physiology

JF - Experimental Physiology

SN - 0958-0670

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