Regulation of CXCR4 conformation by the small GTPase Rac1:implications for HIV infection

Y. Zoughlami, C. Voermans, K. Brussen, K.A. van Dort, N.A. Kootstra, D.M. Maussang-Detaille, M.J. Smit, PL Hordijk, P.B. van Hennik

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The chemokine receptor CXCR4 is a critical regulator of cell migration and serves as a coreceptor for HIV-1. The chemokine stromal cell derived factor-1, also known as CXCL12, binds to CXCR4 and exerts its biologic functions partly through the small guanosine triphosphate hydrolase (GTPase) Rac1 (ras-related C3 botulinum toxin substrate 1). We show in different cell types, including CD34
Original languageEnglish
Pages (from-to)2024-2032
JournalBlood
Volume119
DOIs
Publication statusPublished - 2012

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