TY - JOUR
T1 - Regulation of expression of the amino acid transporter gene BAP3 in Saccharomyces cerevisiae.
AU - de Boer, M.H.
AU - Bebelman, J.P.
AU - Gonçalves, P.
AU - Maat, J.
AU - van Heerikhuizen, H.
AU - Planta, R.J.
PY - 1998
Y1 - 1998
N2 - The BAP3 gene of Saccharomyces cerevisiae encodes a protein with a high similarity to the BAP2 gene product, a high-affinity permease for branched-chain amino acids. In this paper, we show that, like BAP2, the expression of the BAP3 gene in S. cerevisiae is induced by the addition of branched-chain amino acids to the medium. Unexpectedly, most other naturally occurring L-amino acids found in proteins (with the exception of proline, lysine, arginine and histidine) have the same effect on the expression of BAP3. The induction of BAP3 expression appears to be dependent on Stp1p, a nuclear protein, previously shown to be involved in pre-tRNA maturation and also required for the expression of BAP2, as induction is no longer observed in an stp1
AB - The BAP3 gene of Saccharomyces cerevisiae encodes a protein with a high similarity to the BAP2 gene product, a high-affinity permease for branched-chain amino acids. In this paper, we show that, like BAP2, the expression of the BAP3 gene in S. cerevisiae is induced by the addition of branched-chain amino acids to the medium. Unexpectedly, most other naturally occurring L-amino acids found in proteins (with the exception of proline, lysine, arginine and histidine) have the same effect on the expression of BAP3. The induction of BAP3 expression appears to be dependent on Stp1p, a nuclear protein, previously shown to be involved in pre-tRNA maturation and also required for the expression of BAP2, as induction is no longer observed in an stp1
U2 - 10.1046/j.1365-2958.1998.01094.x
DO - 10.1046/j.1365-2958.1998.01094.x
M3 - Article
SN - 0950-382X
VL - 30
SP - 603
EP - 613
JO - Molecular Microbiology
JF - Molecular Microbiology
ER -