Regulation of oxidative phosphorylation: the flexible respiratory network of Paracoccus denitrificans

R J Van Spanning, A P de Boer, W N Reijnders, J.-W. de Gier, C O Delorme, A.H. Stouthamer, H V Westerhoff, N Harms, J. van der Oost

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

Paracoccus denitrificans is a facultative anaerobic bacterium that has the capacity to adjust its metabolic infrastructure, quantitatively and/or qualitatively, to the prevailing growth condition. In this bacterium the relative activity of distinct catabolic pathways is subject to a hierarchical control. In the presence of oxygen the aerobic respiration, the most efficient way of electron transfer-linked phosphorylation, has priority. At high oxygen tensions P. denitrificans synthesizes an oxidase with a relatively low affinity for oxygen, whereas under oxygen limitation a high-affinity oxidase appears specifically induced. During anaerobiosis, the pathways with lower free energy-transducing efficiency are induced. In the presence of nitrate, the expression of a number of dehydrogenases ensures the continuation of oxidative phosphorylation via denitrification. After identification of the structural components that are involved in both the aerobic and the anaerobic respiratory networks of P. denitrificans, the intriguing next challenge is to get insight in its regulation. Two transcription regulators have recently been demonstrated to be involved in the expression of a number of aerobic and/or anaerobic respiratory complexes in P. denitrificans. Understanding of the regulation machinery is beginning to emerge and promises much excitement in discovery.

Original languageEnglish
Pages (from-to)499-512
Number of pages14
JournalJournal of Bioenergetics and Biomembranes
Volume27
Issue number5
DOIs
Publication statusPublished - Oct 1995

Fingerprint

Paracoccus denitrificans
Oxidative Phosphorylation
Oxygen
Oxidoreductases
Anaerobiosis
Denitrification
Anaerobic Bacteria
Nitrates
Respiration
Phosphorylation
Electrons
Bacteria
Growth

Keywords

  • Aerobiosis
  • Anaerobiosis
  • Gene Expression Regulation, Bacterial
  • Genes, Bacterial
  • Homeostasis
  • Models, Biological
  • Mutagenesis
  • Oxidative Phosphorylation
  • Paracoccus denitrificans
  • Comparative Study
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

Cite this

Van Spanning, R. J., de Boer, A. P., Reijnders, W. N., de Gier, J-W., Delorme, C. O., Stouthamer, A. H., ... van der Oost, J. (1995). Regulation of oxidative phosphorylation: the flexible respiratory network of Paracoccus denitrificans. Journal of Bioenergetics and Biomembranes, 27(5), 499-512. https://doi.org/10.1007/BF02110190
Van Spanning, R J ; de Boer, A P ; Reijnders, W N ; de Gier, J.-W. ; Delorme, C O ; Stouthamer, A.H. ; Westerhoff, H V ; Harms, N ; van der Oost, J. / Regulation of oxidative phosphorylation : the flexible respiratory network of Paracoccus denitrificans. In: Journal of Bioenergetics and Biomembranes. 1995 ; Vol. 27, No. 5. pp. 499-512.
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Van Spanning, RJ, de Boer, AP, Reijnders, WN, de Gier, J-W, Delorme, CO, Stouthamer, AH, Westerhoff, HV, Harms, N & van der Oost, J 1995, 'Regulation of oxidative phosphorylation: the flexible respiratory network of Paracoccus denitrificans' Journal of Bioenergetics and Biomembranes, vol. 27, no. 5, pp. 499-512. https://doi.org/10.1007/BF02110190

Regulation of oxidative phosphorylation : the flexible respiratory network of Paracoccus denitrificans. / Van Spanning, R J; de Boer, A P; Reijnders, W N; de Gier, J.-W.; Delorme, C O; Stouthamer, A.H.; Westerhoff, H V; Harms, N; van der Oost, J.

In: Journal of Bioenergetics and Biomembranes, Vol. 27, No. 5, 10.1995, p. 499-512.

Research output: Contribution to JournalReview articleAcademicpeer-review

TY - JOUR

T1 - Regulation of oxidative phosphorylation

T2 - the flexible respiratory network of Paracoccus denitrificans

AU - Van Spanning, R J

AU - de Boer, A P

AU - Reijnders, W N

AU - de Gier, J.-W.

AU - Delorme, C O

AU - Stouthamer, A.H.

AU - Westerhoff, H V

AU - Harms, N

AU - van der Oost, J.

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N2 - Paracoccus denitrificans is a facultative anaerobic bacterium that has the capacity to adjust its metabolic infrastructure, quantitatively and/or qualitatively, to the prevailing growth condition. In this bacterium the relative activity of distinct catabolic pathways is subject to a hierarchical control. In the presence of oxygen the aerobic respiration, the most efficient way of electron transfer-linked phosphorylation, has priority. At high oxygen tensions P. denitrificans synthesizes an oxidase with a relatively low affinity for oxygen, whereas under oxygen limitation a high-affinity oxidase appears specifically induced. During anaerobiosis, the pathways with lower free energy-transducing efficiency are induced. In the presence of nitrate, the expression of a number of dehydrogenases ensures the continuation of oxidative phosphorylation via denitrification. After identification of the structural components that are involved in both the aerobic and the anaerobic respiratory networks of P. denitrificans, the intriguing next challenge is to get insight in its regulation. Two transcription regulators have recently been demonstrated to be involved in the expression of a number of aerobic and/or anaerobic respiratory complexes in P. denitrificans. Understanding of the regulation machinery is beginning to emerge and promises much excitement in discovery.

AB - Paracoccus denitrificans is a facultative anaerobic bacterium that has the capacity to adjust its metabolic infrastructure, quantitatively and/or qualitatively, to the prevailing growth condition. In this bacterium the relative activity of distinct catabolic pathways is subject to a hierarchical control. In the presence of oxygen the aerobic respiration, the most efficient way of electron transfer-linked phosphorylation, has priority. At high oxygen tensions P. denitrificans synthesizes an oxidase with a relatively low affinity for oxygen, whereas under oxygen limitation a high-affinity oxidase appears specifically induced. During anaerobiosis, the pathways with lower free energy-transducing efficiency are induced. In the presence of nitrate, the expression of a number of dehydrogenases ensures the continuation of oxidative phosphorylation via denitrification. After identification of the structural components that are involved in both the aerobic and the anaerobic respiratory networks of P. denitrificans, the intriguing next challenge is to get insight in its regulation. Two transcription regulators have recently been demonstrated to be involved in the expression of a number of aerobic and/or anaerobic respiratory complexes in P. denitrificans. Understanding of the regulation machinery is beginning to emerge and promises much excitement in discovery.

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KW - Anaerobiosis

KW - Gene Expression Regulation, Bacterial

KW - Genes, Bacterial

KW - Homeostasis

KW - Models, Biological

KW - Mutagenesis

KW - Oxidative Phosphorylation

KW - Paracoccus denitrificans

KW - Comparative Study

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1007/BF02110190

DO - 10.1007/BF02110190

M3 - Review article

VL - 27

SP - 499

EP - 512

JO - Journal of Bioenergetics and Biomembranes

JF - Journal of Bioenergetics and Biomembranes

SN - 0145-479X

IS - 5

ER -