Regulation of the activity of lactate dehydrogenases from four lactic acid bacteria

A. Feldman-Salit, S. Hering, H. Messiha, N. Veith, V. Cojocaru, A. Sieg, H.V. Westerhoff, B Kreikemeyer, R. Wade, T. Fiedler

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background: Lactate dehydrogenases (LDHs) are key metabolic enzymes in lactic acid bacteria (LAB). Results: The effects of fructose 1,6-bisphosphate, phosphate, pH, and ionic strength on enzyme activity differ for six LDHs from four LAB. Conclusion: The regulation of LDH activity differs among LAB. Significance: These results have implications for understanding enzyme evolutionary adaptation, for quantitative comparative modeling, and for biotechnological application of LAB. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Original languageEnglish
Pages (from-to)21295-21306
JournalJournal of Biological Chemistry
Volume288
DOIs
Publication statusPublished - 2014

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