Relating mulltidrug resistance phenotypes in the kinetic properties of their drug efflux pumps.

H.V. Westerhoff, A. Riethorst, A.P.M. Jongsma

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The simplest model for pump-mediated multidrug resistance is elaborated quantitatively. The way in which toxicity data should be evaluated to characterize most effectively the drug-efflux pump is then examined. The isotoxic drug dose (D
Original languageEnglish
Pages (from-to)5355-5368
JournalEuropean Journal of Biochemistry
Volume267
DOIs
Publication statusPublished - 2000

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