Relating mulltidrug resistance phenotypes in the kinetic properties of their drug efflux pumps.

H.V. Westerhoff; A. Riethorst; A.P.M. Jongsma

doi:10.1046/j.1432-1327.2000.01559.x

Relating mulltidrug resistance phenotypes in the kinetic properties of their drug efflux pumps.

H.V. Westerhoff, A. Riethorst, A.P.M. Jongsma

Molecular Cell Physiology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The simplest model for pump-mediated multidrug resistance is elaborated quantitatively. The way in which toxicity data should be evaluated to characterize most effectively the drug-efflux pump is then examined. The isotoxic drug dose (D

Original language	English
Pages (from-to)	5355-5368
Journal	European Journal of Biochemistry
Volume	267
DOIs	https://doi.org/10.1046/j.1432-1327.2000.01559.x
Publication status	Published - 2000

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Westerhoff, H. V., Riethorst, A., & Jongsma, A. P. M. (2000). Relating mulltidrug resistance phenotypes in the kinetic properties of their drug efflux pumps. European Journal of Biochemistry, 267, 5355-5368. https://doi.org/10.1046/j.1432-1327.2000.01559.x

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