Relevance of Fcγ receptor and interleukin-10 polymorphisms for meningococcal disease

W. L. Van der Pol; T. W.J. Huizinga; G. Vidarsson; M. W. Van der Linden; M. D. Jansen; V. Keijsers; F. G.J. Leppers-van de Straat; N. A.C. Westerdaal; J. G.J. Van de Winkel; R. G.J. Westendorp

doi:10.1086/324662

Relevance of Fcγ receptor and interleukin-10 polymorphisms for meningococcal disease

W. L. Van der Pol, T. W.J. Huizinga, G. Vidarsson, M. W. Van der Linden, M. D. Jansen, V. Keijsers, F. G.J. Leppers-van de Straat, N. A.C. Westerdaal, J. G.J. Van de Winkel, R. G.J. Westendorp

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The contribution of individual Fcγ receptor (FcγR) subclasses to meningococcal phagocytosis was studied. In addition, functional FcγR polymorphisms were determined in 50 patients with meningococcal disease (MD), in 183 first-degree relatives of MD patients, and in 239 healthy control subjects, to study the association of FcγR genotypes with disease. Efficient internalization of opsonized Neisseria meningitidis serogroup B was mediated via multiple FcγR subclasses on phagocytes. Accordingly, a low-efficiency combination of Fcγ RIIa-R/R131, FcγRIIIa-F/F158, and FcγRIIIb-NA2/2 genotypes was increased significantly in relatives of patients with MD, compared with healthy control subjects (P < .05; odds ratio, 2.6; 95% confidence interval, 1.1-6.3). FcγRIIa and FcγRIIIa genotype distributions differed between patients with sepsis and those with meningitis. Combined genotypes of FcγRIIa and interleukin-10 -1082, which was previously reported as being associated with MD outcome, were distributed randomly in control subjects but not in relatives of patients with MD (P < 01). These data provide further evidence for the association of polymorphic genes on chromosome 1 and MD.

Original language	English
Pages (from-to)	1548-1555
Number of pages	8
Journal	Journal of Infectious Diseases
Volume	184
Issue number	12
DOIs	https://doi.org/10.1086/324662
Publication status	Published - 15 Dec 2001
Externally published	Yes

Bibliographical note

Funding Information:
Received 8 March 2001; revised 13 August 2001; electronically published 3 December 2001. Informed consent was obtained from patients and their relatives before study enrollment. Financial support: Netherlands Organisation for Scientific Research (NWO grant 95-10-624). a Present affiliation: Department of Neurology, University Medical Center, Utrecht, The Netherlands. Reprints or correspondence: Dr. W.-L. van der Pol, University Medical Center, Dept. of Immunology, Laboratory for Immunotherapy, KC.02-085.2, Lundlaan 6, 3584 EA Utrecht, The Netherlands ([email protected]).

Access to Document

10.1086/324662

Persistent URL (handle)

Copy link address

Cite this

Van der Pol, W. L., Huizinga, T. W. J., Vidarsson, G., Van der Linden, M. W., Jansen, M. D., Keijsers, V., Leppers-van de Straat, F. G. J., Westerdaal, N. A. C., Van de Winkel, J. G. J., & Westendorp, R. G. J. (2001). Relevance of Fcγ receptor and interleukin-10 polymorphisms for meningococcal disease. Journal of Infectious Diseases, 184(12), 1548-1555. https://doi.org/10.1086/324662

@article{1051ecf07a0a4eb59a3ce7e3bd0c6b10,

title = "Relevance of Fcγ receptor and interleukin-10 polymorphisms for meningococcal disease",

abstract = "The contribution of individual Fcγ receptor (FcγR) subclasses to meningococcal phagocytosis was studied. In addition, functional FcγR polymorphisms were determined in 50 patients with meningococcal disease (MD), in 183 first-degree relatives of MD patients, and in 239 healthy control subjects, to study the association of FcγR genotypes with disease. Efficient internalization of opsonized Neisseria meningitidis serogroup B was mediated via multiple FcγR subclasses on phagocytes. Accordingly, a low-efficiency combination of Fcγ RIIa-R/R131, FcγRIIIa-F/F158, and FcγRIIIb-NA2/2 genotypes was increased significantly in relatives of patients with MD, compared with healthy control subjects (P < .05; odds ratio, 2.6; 95% confidence interval, 1.1-6.3). FcγRIIa and FcγRIIIa genotype distributions differed between patients with sepsis and those with meningitis. Combined genotypes of FcγRIIa and interleukin-10 -1082, which was previously reported as being associated with MD outcome, were distributed randomly in control subjects but not in relatives of patients with MD (P < 01). These data provide further evidence for the association of polymorphic genes on chromosome 1 and MD.",

author = "{Van der Pol}, {W. L.} and Huizinga, {T. W.J.} and G. Vidarsson and {Van der Linden}, {M. W.} and Jansen, {M. D.} and V. Keijsers and {Leppers-van de Straat}, {F. G.J.} and Westerdaal, {N. A.C.} and {Van de Winkel}, {J. G.J.} and Westendorp, {R. G.J.}",

note = "Funding Information: Received 8 March 2001; revised 13 August 2001; electronically published 3 December 2001. Informed consent was obtained from patients and their relatives before study enrollment. Financial support: Netherlands Organisation for Scientific Research (NWO grant 95-10-624). a Present affiliation: Department of Neurology, University Medical Center, Utrecht, The Netherlands. Reprints or correspondence: Dr. W.-L. van der Pol, University Medical Center, Dept. of Immunology, Laboratory for Immunotherapy, KC.02-085.2, Lundlaan 6, 3584 EA Utrecht, The Netherlands ([email protected]).",

year = "2001",

month = dec,

day = "15",

doi = "10.1086/324662",

language = "English",

volume = "184",

pages = "1548--1555",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "12",

}

TY - JOUR

T1 - Relevance of Fcγ receptor and interleukin-10 polymorphisms for meningococcal disease

AU - Van der Pol, W. L.

AU - Huizinga, T. W.J.

AU - Vidarsson, G.

AU - Van der Linden, M. W.

AU - Jansen, M. D.

AU - Keijsers, V.

AU - Leppers-van de Straat, F. G.J.

AU - Westerdaal, N. A.C.

AU - Van de Winkel, J. G.J.

AU - Westendorp, R. G.J.

N1 - Funding Information: Received 8 March 2001; revised 13 August 2001; electronically published 3 December 2001. Informed consent was obtained from patients and their relatives before study enrollment. Financial support: Netherlands Organisation for Scientific Research (NWO grant 95-10-624). a Present affiliation: Department of Neurology, University Medical Center, Utrecht, The Netherlands. Reprints or correspondence: Dr. W.-L. van der Pol, University Medical Center, Dept. of Immunology, Laboratory for Immunotherapy, KC.02-085.2, Lundlaan 6, 3584 EA Utrecht, The Netherlands ([email protected]).

PY - 2001/12/15

Y1 - 2001/12/15

N2 - The contribution of individual Fcγ receptor (FcγR) subclasses to meningococcal phagocytosis was studied. In addition, functional FcγR polymorphisms were determined in 50 patients with meningococcal disease (MD), in 183 first-degree relatives of MD patients, and in 239 healthy control subjects, to study the association of FcγR genotypes with disease. Efficient internalization of opsonized Neisseria meningitidis serogroup B was mediated via multiple FcγR subclasses on phagocytes. Accordingly, a low-efficiency combination of Fcγ RIIa-R/R131, FcγRIIIa-F/F158, and FcγRIIIb-NA2/2 genotypes was increased significantly in relatives of patients with MD, compared with healthy control subjects (P < .05; odds ratio, 2.6; 95% confidence interval, 1.1-6.3). FcγRIIa and FcγRIIIa genotype distributions differed between patients with sepsis and those with meningitis. Combined genotypes of FcγRIIa and interleukin-10 -1082, which was previously reported as being associated with MD outcome, were distributed randomly in control subjects but not in relatives of patients with MD (P < 01). These data provide further evidence for the association of polymorphic genes on chromosome 1 and MD.

AB - The contribution of individual Fcγ receptor (FcγR) subclasses to meningococcal phagocytosis was studied. In addition, functional FcγR polymorphisms were determined in 50 patients with meningococcal disease (MD), in 183 first-degree relatives of MD patients, and in 239 healthy control subjects, to study the association of FcγR genotypes with disease. Efficient internalization of opsonized Neisseria meningitidis serogroup B was mediated via multiple FcγR subclasses on phagocytes. Accordingly, a low-efficiency combination of Fcγ RIIa-R/R131, FcγRIIIa-F/F158, and FcγRIIIb-NA2/2 genotypes was increased significantly in relatives of patients with MD, compared with healthy control subjects (P < .05; odds ratio, 2.6; 95% confidence interval, 1.1-6.3). FcγRIIa and FcγRIIIa genotype distributions differed between patients with sepsis and those with meningitis. Combined genotypes of FcγRIIa and interleukin-10 -1082, which was previously reported as being associated with MD outcome, were distributed randomly in control subjects but not in relatives of patients with MD (P < 01). These data provide further evidence for the association of polymorphic genes on chromosome 1 and MD.

UR - http://www.scopus.com/inward/record.url?scp=0035892237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035892237&partnerID=8YFLogxK

U2 - 10.1086/324662

DO - 10.1086/324662

M3 - Article

C2 - 11740730

AN - SCOPUS:0035892237

SN - 0022-1899

VL - 184

SP - 1548

EP - 1555

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 12

ER -

Relevance of Fcγ receptor and interleukin-10 polymorphisms for meningococcal disease

Abstract

Bibliographical note

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this